全氟癸酸

化合物

全氟癸酸(英語:Perfluorodecanoic acid,缩写PFDA)是一种全氟羧酸表面活性剂[1],工业上常用于湿润剂阻燃劑[2]。和其它含氟表面活性剂类似,PFDA的使用也引发了健康问题[3],限制了其使用[4]。 PFDA也可以作为研究过氧化物酶体增殖的化学探针[5][6]

全氟癸酸
IUPAC名
2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-nonadecafluorodecanoic acid
识别
CAS号 335-76-2
PubChem 9555
ChemSpider 9181
SMILES
 
  • C(=O)(C(C(C(C(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)O
InChI
 
  • 1S/C10HF19O2/c11-2(12,1(30)31)3(13,14)4(15,16)5(17,18)6(19,20)7(21,22)8(23,24)9(25,26)10(27,28)29/h(H,30,31)
InChIKey PCIUEQPBYFRTEM-UHFFFAOYSA-N
Gmelin 35659
性质
化学式 C10HF19O2
摩尔质量 514.08 g·mol−1
熔点 77-81 °C(269 K)
沸点 218 °C(491 K)
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

参考文献

  1. ^ Reich, Ieva L.; Reich, Hans J.; Menahan, Lawrence A.; Peterson, Richard E. Synthesis of 14C-labeled perfluorooctanoic and perfluorodecanoic acids; purification of perfluorodecanoic acid. Journal of Labelled Compounds and Radiopharmaceuticals. October 1987, 24 (10): 1235–1244. doi:10.1002/jlcr.2580241011. 
  2. ^ Harris, M. Developmental toxicity of perfluorodecanoic acid in C57BL/6N mice. Fundamental and Applied Toxicology. April 1989, 12 (3): 442–448. doi:10.1016/0272-0590(89)90018-3 (英语). 
  3. ^ Danish study links perfluorinated chemicals to miscarriage. Chemical Watch. [25 March 2019] (英语). 
  4. ^ Germany and Sweden propose restrictions on six PFASs. Chemical Watch. 14 May 2015 [25 March 2019]. (原始内容存档于2022-01-19) (英语). 
  5. ^ Vanden Heuvel, John P. Perfluorodecanoic acid as a useful pharmacologic tool for the study of peroxisome proliferation. General Pharmacology: The Vascular System. October 1996, 27 (7): 1123–1129. doi:10.1016/0306-3623(95)00126-3. 
  6. ^ Chen, Li-Chuan; Tatum, Vickie; Glauert, Howard P.; Chow, Ching K. Peroxisome proliferator perfluorodecanoic acid alters glutathione and related enzymes. Journal of Biochemical and Molecular Toxicology. 2001, 15 (2): 107–113. ISSN 1095-6670. doi:10.1002/jbt.6 (英语).