安非他尼
化合物
安非他尼（英语：Amfetaminil或amphetaminil）也叫苯丙苄腈胺[1]或AN-1，商品名Aponeuron，是一种从苯丙胺中提取的兴奋剂药物，开发于1970年代，用于治疗肥胖症、[2]注意力不足过动症[3][4]和发作性嗜睡病。[5]由于存在滥用问题，它在很大程度上已退出临床使用。[6]该药物是苯丙胺的前体药物[7][8]
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| CAS号 | 17590-01-1  |
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| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.037.767 |
| 化学信息 | |
| 化学式 | C17H18N2 |
| 摩尔质量 | 250.338 |
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立体化学
安非他尼是一种具有两个立体异构中心的分子。因此，存在四种不同的立体异构体：
- (R)-2-[(R)-1-苯基丙-2-基氨基]-2-苯基乙腈，CAS号：478392-08-4
- (S)-2-[(S)-1-苯基丙-2-基氨基]-2-苯基乙腈，CAS号：478392-12-0
- (R)-2-[(S)-1-苯基丙-2-基氨基]-2-苯基乙腈，CAS号：478392-10-4
- (S)-2-[(R)-1-苯基丙-2-基氨基]-2-苯基乙腈，CAS号：478392-14-2
参考资料
- ^ Morton IK, Hall JM. Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. 6 December 2012: 13–. ISBN 978-94-011-4439-1.
- ^ Harris LS. The stimulants and hallucinogens under consideration: a brief overview of their chemistry and pharmacology. Drug and Alcohol Dependence. June 1986, 17 (2–3): 107–18. PMID 2874966. doi:10.1016/0376-8716(86)90002-5.
- ^ Meyer-Probst B, Vehreschild T. [Influencing the lack of concentration in hyperkinetic school children with Aponeuron]. Psychiatrie, Neurologie, und Medizinische Psychologie. August 1976, 28 (8): 491–9. PMID 1005547 （德语）.
- ^ Paclt I, Florian J, Brunclíková J, Růzicková I. [Effect of Aponeuron in the treatment of children with hyperkinetic syndrome]. Ceska a Slovenska Psychiatrie. May 1996,. 92 Suppl 1: 41–57. PMID 8768943 （捷克语）.
- ^ Schlesser JL. Drugs Available Abroad - A Guide to Therapeutic Drugs Approved Outside the US.. Detroit: MEDEX Books. 1991.
- ^ Winter E. [Drug abuse and dependence of the amphetamine type with special regard to Amphetaminil (Aponeuron(R))]. Psychiatrie, Neurologie, und Medizinische Psychologie. September 1976, 28 (9): 513–25. PMID 1005549 （德语）.
- ^ Dasgupta A. Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring: A Comprehensive Guide. John Wiley & Sons. 2 July 2012: 96–. ISBN 978-1-118-34785-0.
- ^ AHC Media, LLC. Pediatric Trauma Care II: A clinical reference for physicians and nurses caring for the acutely injured child. AHC Media, LLC. 17 March 2014: 118–. ISBN 978-1-934863-59-6.