硝西泮(英語:Nitrazepam,商品名有Mogadon等)是一种有机化合物,分子式C15H11N3O3,属于苯二氮䓬类药物[3][4],可用作治疗焦慮失眠安眠药[5]

硝西泮
臨床資料
商品名英语Drug nomenclatureAlodorm, Apodorm, Arem, Cerson, Insoma, Insomin, Mogadon, Nitrados, Nitrazadon, Nitrosun, Nitravet, Ormodon, Paxadorm, Remnos, Epam, Apam(Amy Mat Piah & Ed) and Somnite
AHFS/Drugs.com国际药品名称
依賴性Psychological: Moderate[1]
成癮性Moderate[1]
给药途径Oral
ATC碼
法律規範狀態
法律規範
藥物動力學數據
生物利用度53–94%
药物代谢Hepatic
生物半衰期16–38 hours
排泄途徑Renal
识别信息
  • 7-nitro-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS号146-22-5  checkY
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.005.151 編輯維基數據鏈接
化学信息
化学式C15H11N3O3
摩尔质量281.27 g·mol−1
3D模型(JSmol英语JSmol
  • [O-][N+](C1=CC2=C(C=C1)NC(CN=C2C3=CC=CC=C3)=O)=O
  • InChI=1S/C15H11N3O3/c19-14-9-16-15(10-4-2-1-3-5-10)12-8-11(18(20)21)6-7-13(12)17-14/h1-8H,9H2,(H,17,19) checkY
  • Key:KJONHKAYOJNZEC-UHFFFAOYSA-N checkY

参考文献

  1. ^ 1.0 1.1 Schifano F. Misuse and abuse of pregabalin and gabapentin: cause for concern?. CNS Drugs. June 2014, 28 (6): 491–496. PMID 24760436. doi:10.1007/s40263-014-0164-4 . 
  2. ^ Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control]. Diário Oficial da União. 2023-03-31 (2023-04-04) [2023-08-16]. (原始内容存档于2023-08-03) (巴西葡萄牙语). 
  3. ^ Benzodiazepine Names. non-benzodiazepines.org.uk. [2008-12-29]. (原始内容存档于2008-12-08). 
  4. ^ INSOMIN tabletti 5 mg. laaketietokeskus.fi. [2024-01-03]. (原始内容存档于2019-03-06). 
  5. ^ Hypnotics and anxiolytics. BNF. [2014-08-14]. (原始内容存档于2021-04-27). 

外部链接