磺胺甲噻二唑
磺胺甲噻二唑是一种磺胺类药物,其INN名称是“Sulfamethizole”。该药物可用于治疗由细菌感染引起的疾病等病症。该药物在血液中的半衰期约为3-8小时,在大鼠体内的LD50(半致死量)为1.8564mol/kg。该药物主要经肝代谢。[1][2]
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臨床資料 | |
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AHFS/Drugs.com | Micromedex详细消费者药物信息 |
MedlinePlus | a682231 |
ATC碼 | |
藥物動力學數據 | |
血漿蛋白結合率 | 98–99% |
生物半衰期 | 3–8 hours |
识别信息 | |
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CAS号 | 144-82-1 ![]() |
PubChem CID | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.005.129 |
化学信息 | |
化学式 | C9H10N4O2S2 |
摩尔质量 | 270.333 g/mol |
3D模型(JSmol) | |
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参考文献
拓展阅读
- Ratanajamit C, Skriver M, Nørgaard M, Jepsen P, Schønheyder H, Sørensen H. Adverse pregnancy outcome in users of sulfamethizole during pregnancy: a population-based observational study.. J Antimicrob Chemother. 2003, 52 (5): 837–41. PMID 14519675. doi:10.1093/jac/dkg438.
- Kerrn M, Frimodt-Møller N, Espersen F. Effects of Sulfamethizole and Amdinocillin against Escherichia coli Strains (with Various Susceptibilities) in an Ascending Urinary Tract Infection Mouse Model. Antimicrob Agents Chemother. 2003, 47 (3): 1002–9. PMC 149286 . PMID 12604534. doi:10.1128/AAC.47.3.1002-1009.2003.
- Watanabe H, Hastings J. Inhibition of bioluminescence in Photobacterium phosphoreum by sulfamethizole and its stimulation by thymine. Biochim Biophys Acta. 1990, 1017 (3): 229–34. PMID 2372557. doi:10.1016/0005-2728(90)90189-B.
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