罗雄龙

化合物

罗雄龙INN:rosterolone;开发代号:SH-434),也叫17α-丙基美睾酮17α-propylmesterolone)是一种类固醇抗雄激素,于1984年首次被描述,开发用于局部给药,但从未上市。[1][2]它在治疗痤疮方面显示出一定的功效,但无论是局部还是全身给药都缺乏全身作用。[3][1][2]

罗雄龙
臨床資料
其他名稱SH-434、17α-丙基美睾酮、17β-羟基-1α-甲基-17α-丙基-5α-雄-3-酮
给药途径局部给药
识别信息
  • (1S,5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-1,10,13-trimethyl-17-propyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-one
CAS号79243-67-7
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.071.904 編輯維基數據鏈接
化学信息
化学式C23H38O2
摩尔质量346.56 g·mol−1
3D模型(JSmol英语JSmol
  • CCCC1(CCC2C1(CCC3C2CCC4C3(C(CC(=O)C4)C)C)C)O
  • InChI=1S/C23H38O2/c1-5-10-23(25)12-9-19-18-7-6-16-14-17(24)13-15(2)22(16,4)20(18)8-11-21(19,23)3/h15-16,18-20,25H,5-14H2,1-4H3/t15-,16-,18-,19-,20-,21-,22-,23-/m0/s1
  • Key:IMFNBOMNWHWKQD-MXENSADDSA-N

参考资料

  1. ^ 1.0 1.1 Luderschmidt C, Eiermann W, Jawny J, Bidlingmaier F, Ring J. 17 alpha-Propylmesterolone (SH 434): an antiandrogenic sebosuppressive substance not influencing circulating testosterone concentrations. Experimental studies in Syrian hamsters. Naunyn-Schmiedeberg's Archives of Pharmacology. December 1984, 328 (2): 214–8. PMID 6527707. S2CID 26451613. doi:10.1007/BF00512076. 
  2. ^ 2.0 2.1 Singh SM, Gauthier S, Labrie F. Androgen receptor antagonists (antiandrogens): structure-activity relationships. Current Medicinal Chemistry. February 2000, 7 (2): 211–47. PMID 10637363. doi:10.2174/0929867003375371. 
  3. ^ Neumann F, Töpert M. Antiandrogens and Hair Growth: Basic Concepts and Experimental Research. Orfanos CE, Happle R (编). Hair and Hair Diseases. Springer. 1990: 791–826. ISBN 978-3-642-74614-7. doi:10.1007/978-3-642-74612-3_34.