酮醇酸还原异构酶

酮醇酸还原异构酶(英語:ketol-acid reductoisomeraseEC 1.1.1.86页面存档备份,存于互联网档案馆))是一种以NAD+NADP+受体、作用于供体CH-OH基团上的氧化还原酶。这种催化以下酶促反应

酮醇酸还原异构酶
识别码
EC編號 1.1.1.86
CAS号 9075-02-9
数据库
IntEnz IntEnz浏览
BRENDA英语BRENDA BRENDA入口
ExPASy英语ExPASy NiceZyme浏览
KEGG KEGG入口
MetaCyc英语MetaCyc 代谢路径
PRIAM英语PRIAM_enzyme-specific_profiles 概述
PDB RCSB PDB PDBj PDBe PDBsum
基因本体 AmiGO / EGO
(R)-2,3-二羟基-3-甲基丁酸 + NADP+ (S)-2-羟基-2-甲基-3-氧代丁酸 + NADPH + H+

酮醇酸还原异构酶还能将2-乙酰-2-羟基丁酸催化转化为2,3-二羟基-3-甲基戊酸

参考文献

  • Arfin SM, Umbarger HE. Purification and properties of the acetohydroxy acid isomeroreductase of Salmonella typhimurium. J. Biol. Chem. 1969, 244 (5): 1118–27. PMID 4388025. 
  • Hill RK, Sawada S and Arfin SM. Stereochemistry of valine and isoleucine biosynthesis. IV Synthesis, configuration, and enzymatic specificity of alpha-acetolactate and alpha-aceto-alpha-hydroxybutyrate. Bioorg. Chem. 1979, 8 (2): 175–189. doi:10.1016/0045-2068(79)90003-8. 
  • Kiritani K, Narise S and Wagner RP. The reductoisomerase of Neurospora crassa. J. Biol. Chem. 1966, 241: 2047–2051. 
  • Satyanarayana T, Radhakrishnan AN. Biosynthesis of valine and isoleucine in plants. 3. Reductoisomerase of Phaseolus radiatus. Biochim. Biophys. Acta. 1965, 110 (2): 380–8. PMID 5866387.