黄体生成素β亚基
位於19號人類染色體的基因
黄体生成素β亚基（英語：Luteinizing hormone subunit beta 或 lutropin subunit beta ）是一种由人类基因LHB 编码的蛋白质[1][2]。
| Luteinizing hormone beta polypeptide 黄体生成素β多肽 | |||||||||||||
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| 标识 | |||||||||||||
| 代号 | LHB; CGB4; LSH-B; hLHB | ||||||||||||
| 扩展标识 | 遗传学：152780 鼠基因：96782 同源基因：81806 GeneCards: LHB Gene | ||||||||||||
| RNA表达模式 | |||||||||||||
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| 更多表达数据 | |||||||||||||
| 直系同源体 | |||||||||||||
| 物种 | 人类 | 小鼠 | |||||||||||
| Entrez | 3972 | 16866 | |||||||||||
| Ensembl | ENSG00000104826 | ENSMUSG00000038194 | |||||||||||
| UniProt | P01229 | G3X9G6 | |||||||||||
| mRNA序列 | NM_000894 | NM_008497 | |||||||||||
| 蛋白序列 | NP_000885 | NP_032523 | |||||||||||
| 基因位置 |
Chr 19: 49.52 – 49.52 Mb |
Chr 7: 45.42 – 45.42 Mb | |||||||||||
| PubMed查询 | [1] | [2] | |||||||||||
基因
该基因位于19号染色体q13.3，编码黄体生成素的β亚基[2]。而在马科动物中，黄体生成素的β亚基和绒毛膜促性腺激素的β亚基是由一个基因编码的[3]。
功能
临床意义
参考文献
- ^ Sairam MR, Li CH. Human pituitary lutropin. Isolation, properties, and the complete amino acid sequence of the beta-subunit. Biochim Biophys Acta. Feb 1976, 412 (1): 70–81. PMID 1191677.
- ^ 2.0 2.1 Entrez Gene: LHB luteinizing hormone beta polypeptide.
- ^ Sherman GB, Wolfe MW, Farmerie TA, Clay CM, Threadgill DS, Sharp DC, Nilson JH. A single gene encodes the beta-subunits of equine luteinizing hormone and chorionic gonadotropin. Mol. Endocrinol. June 1992, 6 (6): 951–9. PMID 1379674. doi:10.1210/me.6.6.951.
延伸阅读
- Keutmann HT, Hua QX, Weiss MA. Structure of a receptor-binding fragment from human luteinizing hormone beta-subunit determined by [1H]- and [15N]nuclear magnetic resonance spectroscopy. Mol. Endocrinol. 1992, 6 (6): 904–13. PMID 1495492. doi:10.1210/me.6.6.904.
- Weiss J, Axelrod L, Whitcomb RW; et al. Hypogonadism caused by a single amino acid substitution in the beta subunit of luteinizing hormone. N. Engl. J. Med. 1992, 326 (3): 179–83. PMID 1727547. doi:10.1056/NEJM199201163260306.
- Weisshaar G, Hiyama J, Renwick AG, Nimtz M. NMR investigations of the N-linked oligosaccharides at individual glycosylation sites of human lutropin. Eur. J. Biochem. 1991, 195 (1): 257–68. PMID 1991473. doi:10.1111/j.1432-1033.1991.tb15702.x.
- Jameson JL, Lindell CM, Habener JF. Evolution of different transcriptional start sites in the human luteinizing hormone and chorionic gonadotropin beta-subunit genes. DNA. 1986, 5 (3): 227–34. PMID 2424697. doi:10.1089/dna.1986.5.227.
- Keutmann HT, Charlesworth MC, Mason KA; et al. A receptor-binding region in human choriogonadotropin/lutropin beta subunit. Proc. Natl. Acad. Sci. U.S.A. 1987, 84 (7): 2038–42. PMC 304579
. PMID 3470775. doi:10.1073/pnas.84.7.2038. - Shome B, Parlow AF. The primary structure of the hormone-specific, beta subunit of human pituitary luteinizing hormone (hLH). J. Clin. Endocrinol. Metab. 1973, 36 (3): 618–21. PMID 4685398. doi:10.1210/jcem-36-3-618.
- Closset J, Hennen G, Lequin RM. Human luteinizing hormone. The amino acid sequence of the subunit. FEBS Lett. 1973, 29 (2): 97–100. PMID 4719207. doi:10.1016/0014-5793(73)80534-4.
- Talmadge K, Vamvakopoulos NC, Fiddes JC. Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone. Nature. 1984, 307 (5946): 37–40. PMID 6690982. doi:10.1038/307037a0.
- Beitins IZ, Axelrod L, Ostrea T; et al. Hypogonadism in a male with an immunologically active, biologically inactive luteinizing hormone: characterization of the abnormal hormone. J. Clin. Endocrinol. Metab. 1981, 52 (6): 1143–9. PMID 6785294. doi:10.1210/jcem-52-6-1143.
- Berger P, Kranewitter W, Madersbacher S; et al. Eutopic production of human chorionic gonadotropin beta (hCG beta) and luteinizing hormone beta (hLH beta) in the human testis. FEBS Lett. 1994, 343 (3): 229–33. PMID 7513655. doi:10.1016/0014-5793(94)80561-X.
- Keutmann HT, Rubin DA. A subunit interaction site in human luteinizing hormone: identification by photoaffinity cross-linking. Endocrinology. 1993, 132 (3): 1305–12. PMID 7679977. doi:10.1210/en.132.3.1305.
- Herrlich A, Kühn B, Grosse R; et al. Involvement of Gs and Gi proteins in dual coupling of the luteinizing hormone receptor to adenylyl cyclase and phospholipase C. J. Biol. Chem. 1996, 271 (28): 16764–72. PMID 8663226. doi:10.1074/jbc.271.28.16764.
- Muyan M, Furuhashi M, Sugahara T, Boime I. The carboxy-terminal region of the beta-subunits of luteinizing hormone and chorionic gonadotropin differentially influence secretion and assembly of the heterodimers. Mol. Endocrinol. 1997, 10 (12): 1678–87. PMID 8961276. doi:10.1210/me.10.12.1678.
- Roy AC, Liao WX, Chen Y; et al. Identification of seven novel mutations in LH beta-subunit gene by SSCP. Mol. Cell. Biochem. 1997, 165 (2): 151–3. PMID 8979264.
- Liao WX, Roy AC, Chan C; et al. A new molecular variant of luteinizing hormone associated with female infertility. Fertil. Steril. 1998, 69 (1): 102–6. PMID 9457942. doi:10.1016/S0015-0282(97)00445-7.
- O'Connor JF, Kovalevskaya G, Birken S; et al. The expression of the urinary forms of human luteinizing hormone beta fragment in various populations as assessed by a specific immunoradiometric assay. Hum. Reprod. 1998, 13 (4): 826–35. PMID 9619532. doi:10.1093/humrep/13.4.826.
- Takahashi K, Kurioka H, Ozaki T; et al. Increased prevalence of luteinizing hormone beta-subunit variant in Japanese infertility patients. Hum. Reprod. 1999, 13 (12): 3338–44. PMID 9886510. doi:10.1093/humrep/13.12.3338.
- Elter K, Erel CT, Cine N; et al. Role of the mutations Trp8 => Arg and Ile15 => Thr of the human luteinizing hormone beta-subunit in women with polycystic ovary syndrome. Fertil. Steril. 1999, 71 (3): 425–30. PMID 10065776. doi:10.1016/S0015-0282(98)00491-9.
- Jiang M, Pakarinen P, Zhang FP; et al. A common polymorphic allele of the human luteinizing hormone beta-subunit gene: additional mutations and differential function of the promoter sequence. Hum. Mol. Genet. 1999, 8 (11): 2037–46. PMID 10484773. doi:10.1093/hmg/8.11.2037.
