1-氨基-1-羧基茚满-5-磷酸
化合物
1-氨基-1-羧基茚满-5-磷酸（APICA）是一种有机化合物，化学式为C10H12NO5P。它是一种药物，可用于神经科学研究。它是II组代谢型谷氨酸受体 (mGluR2/3) 的选择性拮抗剂。[1][2][3]它可以3-溴苯甲醛和亚磷酸二乙酯为原料经多步反应制得。[2]
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| CAS号 | 170847-18-4  |
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| 化学信息 | |
| 化学式 | C10H12NO5P |
| 摩尔质量 | 257.18 g·mol−1 |
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参考文献
- ^ Ma D, Tian H, Sun H, Kozikowski AP, Pshenichkin S, Wroblewski JT. Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists.. Bioorganic & Medicinal Chemistry Letters. May 1997, 7 (9): 1195–1198. doi:10.1016/S0960-894X(97)00177-7
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- ^ 2.0 2.1 Ma D, Tian H, Zou G. Asymmetric Strecker-Type Reaction of alpha-Aryl Ketones. Synthesis of (S)-alphaM4CPG, (S)-MPPG, (S)-AIDA, and (S)-APICA, the Antagonists of Metabotropic Glutamate Receptors. The Journal of Organic Chemistry. January 1999, 64 (1): 120–125. PMID 11674092. doi:10.1021/jo981297a.
- ^ Xi ZX, Baker DA, Shen H, Carson DS, Kalivas PW. Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens. The Journal of Pharmacology and Experimental Therapeutics. January 2002, 300 (1): 162–71. PMID 11752112. doi:10.1124/jpet.300.1.162.
