TMC-310911
化合物
(重定向自1000287-05-7)
TMC-310911(也称ASC-09)是一种最初被研究用于治疗HIV/AIDS的抗病毒药物。它是一种蛋白酶抑制剂,与达芦那韦有关。[1][2]尽管TMC-310911在开发后,其最终用途不是用于治疗艾滋病,但对于其它病毒性疾病的治疗研究仍在进行。它在2020年3月进入了COVID-19治疗的临床试验阶段。[3][4]
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CAS号 | 1000287-05-7 |
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化学式 | C38H53N5O7S2 |
摩尔质量 | 755.99 |
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参见
参考文献
- ^ Dierynck I, Van Marck H, Van Ginderen M, Jonckers TH, Nalam MN, Schiffer CA, Raoof A, Kraus G, Picchio G. TMC310911, a novel human immunodeficiency virus type 1 protease inhibitor, shows in vitro an improved resistance profile and higher genetic barrier to resistance compared with current protease inhibitors. Antimicrobial Agents and Chemotherapy. December 2011, 55 (12): 5723–31. PMC 3232804 . PMID 21896904. doi:10.1128/AAC.00748-11.
- ^ Ghosh AK, Brindisi M. Organic carbamates in drug design and medicinal chemistry. Journal of Medicinal Chemistry. April 2015, 58 (7): 2895–940. PMC 4393377 . PMID 25565044. doi:10.1021/jm501371s.
- ^ Catapang JK, Billones JB. On the Generation of Novel Ligands for SARS-CoV-2 Protease and ACE2 Receptor via Constrained Graph Variational Autoencoders. ChemRxiv. March 2020. doi:10.26434/chemrxiv.12011157.v3.
- ^ McGrath J. All the COVID-19 vaccines and treatments currently in clinical trials. Digital Trends. 2 April 2020 [6 April 2020]. (原始内容存档于2020-04-14).