11β-甲氧基雌二醇
11β-甲氧基雌二醇(英語:11β-Methoxyestradiol,缩写11β-MeOE2,开发代号RU-2504)是一种人工合成的雌激素类甾体化合物,分子式C19H26O3,从未上市[1][2][3],结构上与莫克雌醇(11β-甲氧基-17α-乙炔基雌二醇)类似[3][2],其对雌激素受体的亲和力约为雌二醇的 86%[1][2]。
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其他名稱 | 11β-MeOE2; 11βOMeEST; RU-2504; 11β-Methoxyestra-1,3,5(10)-triene-3,17β-diol |
藥物類別 | Estrogen |
识别信息 | |
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CAS号 | 21507-14-2 ![]() |
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化学信息 | |
化学式 | C19H26O3 |
摩尔质量 | 302.41 g·mol−1 |
3D模型(JSmol) | |
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参考资料
- ^ 1.0 1.1 Wolohan P, Reichert DE. CoMSIA and docking study of rhenium based estrogen receptor ligand analogs. Steroids. March 2007, 72 (3): 247–260. PMC 1964785 . PMID 17280694. doi:10.1016/j.steroids.2006.11.011.
- ^ 2.0 2.1 2.2 Katzenellenbogen JA, Muthyala R. Interactions of exogenous endocrine active substances with nuclear receptors. Pure and Applied Chemistry. 2003, 75 (11–12): 1797–1817. ISSN 1365-3075. S2CID 86680540. doi:10.1351/pac200375111797.
- ^ 3.0 3.1 Azadian-Boulanger G, Bertin D. Synthèse et activité utérotrophique des 11β-méthoxy estradiol 11β-méthoxy estriol et 11β-méthoxy 17α-éthynyl estradiol [Synthesis and uterotropic activity of 11β-methoxyestradiol, 11β-methoxyestriol, and 11β-methoxy-17α-ethynylestradiol]. Chimica Therapeutica. 1973, 8 (4): 451–454. ISSN 0009-4374.
The prepn. and estrogenic activity of the 11β-methoxylated derivs. of estradiol, estriol, and 17α-ethynylestradiol were described. When administered orally to mice, the 3 compds. were from 10 to 1000 times more active than the corresponding nonmethoxylated estrogens.