2,5-𫫇唑烷二酮
化合物
甘氨酸N-羧酸酐(英语:Glycine N-carboxyanhydride),也叫2,5-𫫇唑烷二酮(2,5-Oxazolidinedione),是一种有机化合物,化学式为HNCH(CO)2O。无色固体,是甘氨酸光气化的产物。[3][4]甘氨酸N-羧酸酐是氨基酸N-羧酸酐中最简单的成员。它也是2,5-𫫇唑烷二酮杂环家族的母体。
甘氨酸N-羧酸酐 | |
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别名 | 2,5-𫫇唑烷二酮 𫫇唑烷-2,5-二酮 |
识别 | |
CAS号 | 2185-00-4 ![]() |
PubChem | 75136 |
ChemSpider | 67684 |
SMILES |
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性质 | |
化学式 | C3H3NO3 |
摩尔质量 | 101.06 g·mol−1 |
外观 | 白色固体 |
密度 | 1.74 g/cm3[1] |
熔点 | 96-98 °C(369-371 K)([2]) |
危险性 | |
GHS危险性符号![]() ![]() | |
GHS提示词 | Danger |
H-术语 | H315, H318, H335 |
P-术语 | P261, P264, P264+265, P271, P280, P302+352, P304+340, P305+354+338, P317, P319, P321, P332+317, P362+364, P403+233 |
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。 |
其它衍生物
参见
参考资料
- ^ Kanazawa, Hitoshi; Matsuura, Yoshiki; Tanaka, Nobuo; Kakudo, Masao; Komoto, Tadashi; Kawai, Tohru. The Crystal and Molecular Structure ofN-Carboxy Anhydride of Glycine. Bulletin of the Chemical Society of Japan. 1976, 49 (4): 954–956. doi:10.1246/bcsj.49.954.
- ^ Wilder, Renee; Mobashery, Shahriar. The use of triphosgene in preparation of N-carboxy .alpha.-amino acid anhydrides. The Journal of Organic Chemistry. 1992, 57 (9): 2755–2756. doi:10.1021/jo00035a044.
- ^ Kricheldorf HR. Polypeptides and 100 years of chemistry of alpha-amino acid N-carboxyanhydrides. Angewandte Chemie. September 2006, 45 (35): 5752–84. PMID 16948174. doi:10.1002/anie.200600693.
- ^ Tian ZY, Zhang Z, Wang S, Lu H. A Moisture-Tolerant Route to Unprotected α/β-Amino Acid N-carboxyanhydrides and Facile Synthesis of Hyperbranched Polypeptides. Nature Communications. October 2021, 12 (1): 5810. Bibcode:2021NatCo..12.5810T. PMC 8490447 . PMID 34608139. doi:10.1038/s41467-021-25689-y.
- ^ Sucu BO, Ocal N, Erden I. Direct synthesis of imidazolidin-4-ones via cycloadditions of imines with a Leuchs' anyhdride. Tetrahedron Letters. 2015, 56 (20): 2590–2. doi:10.1016/j.tetlet.2015.04.002.