3-甲磺酰基丙腈

3-甲磺酰基丙腈是一种有机化合物,化学式为C4H7NO2S。它可由3-溴丙腈和甲硫醇钠反应(或2-氯乙基甲硫醚和氰化钾反应[3]),再经过氧化氢氧化制得。[4]它可以用作药物治疗炎症、消除疼痛。[5]

3-甲磺酰基丙腈
IUPAC名
3-methylsulfonylpropanenitrile
别名 3-甲基磺酰基丙腈
Dapansutrile
OLT 1177
识别
CAS号 54863-37-5  checkY
PubChem 12714644
ChemSpider 14967771
SMILES
 
  • CS(=O)(=O)CCC#N
EINECS 821-352-9
KEGG D10920
性质
化学式 C4H7NO2S
摩尔质量 133.17 g·mol−1
熔点 71—72 °C(344—345 K)[1]
68 °C(341 K)[2]
溶解性 可溶于水、乙醇,难溶于乙醚[1]
危险性
GHS危险性符号
《全球化学品统一分类和标签制度》(简称“GHS”)中有害物质的标签图案
GHS提示词 警告
H-术语 H302, H315, H319, H335
P-术语 P261, P264, P270, P271, P280, P301+312, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

参考文献

  1. ^ 1.0 1.1 Anders Kjær, Franz Marcus, Josef Conti. isoThiocyanates. VI. A Synthesis of Cheiroline (gamma-Methylsulphonylpropyl isoThiocyanate).. Acta Chemica Scandinavica. 1953, 7: 1370–1374 [2020-12-19]. ISSN 0904-213X. doi:10.3891/acta.chem.scand.07-1370. (原始内容存档于2018-06-02) (英语). 
  2. ^ Bell, Richard; Cottam, Peter D.; Davies, John; Jones, D. Neville. Synthesis of alkenyl sulfoxides by intramolecular and intermolecular addition of sulfenic acids to alkynes. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981. 7: 2106-2115. ISSN: 0300-922X.
  3. ^ Jones, Gerald S.; Goodrich, Scott A. Process for preparing 3-(methylsulfonyl)​propionitrile. 2017. US 9815781 B1.
  4. ^ St. Laurent, Joseph P.; Jones, Gerald S.; Bresse, David M. Process for preparing 3-methylsulfonylpropionitrile by reacting 3-bromopropionitrile and sodium methylsulfinate in an organic solvent. 2013. US 20130225865 A1.
  5. ^ 约瑟夫·P·圣劳伦特. 用于治疗炎症和疼痛的3-甲磺酰基丙腈. 2011. CN103260613A.