4-(4-甲基-1-哌嗪基)苯胺

化合物

4-(4-甲基-1-哌嗪基)苯胺是一种有机化合物,化学式为C11H17N3。它可由1-甲基-4-(4-硝基苯基)哌嗪的还原反应制得,[2]或由4-溴苯胺N-甲基哌嗪磷酸钾的存在下反应得到。[3]它和氯乙酰氯反应,可以得到N-氯乙酰基-4-(4-甲基-1-哌嗪基)苯胺。[4]

4-(4-甲基-1-哌嗪基)苯胺
别名 4-(4-甲基哌嗪基)苯胺
4-甲基-1-(4-氨基苯基)哌嗪
识别
CAS号 16153-81-4  checkY
性质
化学式 C11H17N3
摩尔质量 191.27 g·mol−1
熔点 93 °C(366 K)[1]
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

参考文献

  1. ^ Loewe, Heinz; Mieth, H.; Urbanietz, Josef. 4-Aminoquinoline. Arzneimittel-Forschung, 1966. 16 (10): 1306-1310. ISSN 0004-4172.
  2. ^ Yuan-Yuan Hei, Ying Shen, Jin Wang, Hao Zhang, Hong-Yi Zhao, Minhang Xin, Yong-Xiao Cao, Yan Li, San-Qi Zhang. Synthesis and evaluation of 2,9-disubstituted 8-phenylthio/phenylsulfinyl-9H-purine as new EGFR inhibitors. Bioorganic & Medicinal Chemistry. 2018-05, 26 (8): 2173–2185 [2021-10-11]. doi:10.1016/j.bmc.2018.03.025 (英语). 
  3. ^ Subhajit Bhunia, S. Vijay Kumar, Dawei Ma. N , N ′-Bisoxalamides Enhance the Catalytic Activity in Cu-Catalyzed Coupling of (Hetero)Aryl Bromides with Anilines and Secondary Amines. The Journal of Organic Chemistry. 2017-12-01, 82 (23): 12603–12612 [2021-10-11]. ISSN 0022-3263. doi:10.1021/acs.joc.7b02363. (原始内容存档于2021-12-15) (英语). 
  4. ^ Huan Liu, Yi Li, Xiang-Ying Wang, Bo Wang, Hai-Yun He, Ji-Yan Liu, Ming-Li Xiang, Jun He, Xiao-Hua Wu, Li Yang. Synthesis, preliminary structure–activity relationships, and in vitro biological evaluation of 6-aryl-3-amino-thieno[2,3-b]pyridine derivatives as potential anti-inflammatory agents. Bioorganic & Medicinal Chemistry Letters. 2013-04, 23 (8): 2349–2352 [2021-10-11]. doi:10.1016/j.bmcl.2013.02.059. (原始内容存档于2021-10-20) (英语).