8-苯基茶碱

化合物

8-苯基茶碱(英語:8-Phenyltheophylline,缩写8-PT,或称为8-苯基-1,3-二甲基黄嘌呤,8-phenyl-1,3-dimethylxanthine),分子式C13H12N4O2,是一种黄嘌呤衍生物,可作为腺苷受體A1A2A的选择性拮抗剂,但不具备磷酸二酯酶抑制药活性。[1][2][3]

8-苯基茶碱
Skeletal formula of 8-phenyltheophylline
Ball-and-stick model of the 8-phenyltheophylline molecule
臨床資料
ATC碼
  • 未分配
识别信息
  • 8-Phenyl-1,3-dimethyl-7H-purine-2,6-dione
CAS号961-45-5  checkY
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C13H12N4O2
摩尔质量256.27 g·mol−1
3D模型(JSmol英语JSmol
  • Cn3c(=O)c2nc(c1ccccc1)[nH]c2n(C)c3=O
  • InChI=1S/C13H12N4O2/c1-16-11-9(12(18)17(2)13(16)19)14-10(15-11)8-6-4-3-5-7-8/h3-7H,1-2H3,(H,14,15) checkY
  • Key:PJFMAVHETLRJHJ-UHFFFAOYSA-N checkY

参考文献

  1. ^ Scotini E, Carpenedo F, Fassina G. New derivatives of methyl-xanthines: effect of thiocaffeine thiotheophylline and 8-phenyltheophylline on lipolysis and on phosphodiesterase activities. Pharmacological Research Communications. February 1983, 15 (2): 131–43. PMID 6844374. doi:10.1016/s0031-6989(83)80055-1. 
  2. ^ Rabe KF, Magnussen H, Dent G. Theophylline and selective PDE inhibitors as bronchodilators and smooth muscle relaxants. The European Respiratory Journal. April 1995, 8 (4): 637–42. PMID 7664866. doi:10.1183/09031936.95.08040637. 
  3. ^ Howell LL, Morse WH, Spealman RD. Respiratory effects of xanthines and adenosine analogs in rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics. September 1990, 254 (3): 786–91. PMID 2395111. 

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