贝美司琼
化合物
(重定向自C15H17Cl2NO2)
贝美司琼(INN:bemesetron;开发代号:MDL-72222)是一种用作5-HT3受体拮抗剂的药物。[1]它具有与甲氧氯普胺相当的止吐作用,[2]然而它不用于临床,其主要应用是在科学研究中,研究5-HT3受体与滥用药物作用的关系。[3][4][5][6]
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CAS号 | 40796-97-2 |
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CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.164.757 |
化学信息 | |
化学式 | C15H17Cl2NO2 |
摩尔质量 | 314.21 g·mol−1 |
3D模型(JSmol) | |
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参考资料
- ^ Shearman GT, Tolcsvai L. Effect of the selective 5-HT3 receptor antagonists ICS 205-930 and MDL 72222 on 5-HTP-induced head shaking and behavioral symptoms induced by 5-methoxy-N,N,dimethyltryptamine in rats: comparison with some other 5-HT receptor antagonists. Psychopharmacology. 1987, 92 (4): 520–3. PMID 3114804. S2CID 25814825. doi:10.1007/bf00176488.
- ^ Homesley HD, Hahne WF, McLees B, et al. Randomized comparison of the antiemetic efficacy of a serotonin type 3 receptor antagonist (MDL 72,222) with a high-dose metoclopramide regimen. Am. J. Clin. Oncol. April 1993, 16 (2): 175–9. PMID 8452114. S2CID 11733418. doi:10.1097/00000421-199304000-00020.
- ^ McKinzie DL, McBride WJ, Murphy JM, Lumeng L, Li TK. Effects of MDL 72222, a serotonin3 antagonist, on operant responding for ethanol by alcohol-preferring P rats. Alcohol. Clin. Exp. Res. October 2000, 24 (10): 1500–4. PMID 11045857. doi:10.1111/j.1530-0277.2000.tb04567.x.
- ^ Kankaanpää A, Meririnne E, Seppälä T. 5-HT3 receptor antagonist MDL 72222 attenuates cocaine- and mazindol-, but not methylphenidate-induced neurochemical and behavioral effects in the rat. Psychopharmacology. February 2002, 159 (4): 341–50. PMID 11823886. S2CID 21614467. doi:10.1007/s00213-001-0939-4.
- ^ Kos T, Popik P, Pietraszek M, et al. Effect of 5-HT3 receptor antagonist MDL 72222 on behaviors induced by ketamine in rats and mice. Eur Neuropsychopharmacol. May 2006, 16 (4): 297–310. PMID 16288851. S2CID 43575963. doi:10.1016/j.euroneuro.2005.10.001.
- ^ Yoo JH, Nam YS, Lee SY, Jang CG. Dopamine neurotransmission is involved in the attenuating effects of 5-HT3 receptor antagonist MDL 72222 on acute methamphetamine-induced locomotor hyperactivity in mice. Synapse. January 2008, 62 (1): 8–13. PMID 17948891. S2CID 20699645. doi:10.1002/syn.20461.
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