CCL9(英語:Chemokine (C-C motif) ligand 9)是一个小型的细胞因子,属于CC趋化因子家族。它的别名有巨噬细胞炎性蛋白-1γ(英語:macrophage inflammatory protein-1 gammaMIP-1γ), 巨噬细胞炎症蛋白相关蛋白-2(英語:macrophage inflammatory protein-related protein-2MRP-2)以及在啮齿类中使用的CCF18。CCL9还曾经被定名为CCL10,但这个名称已不再使用。

趋化因子(C-C基序)配体9
Chemokine (C-C motif) ligand 9
标识
代号 Ccl9; CCF18; MRP-2; Scya10; Scya9
扩展标识 鼠基因104533 同源基因86734 GeneCards: Ccl9 Gene
直系同源体
物种 人类 小鼠
Entrez 20308 20308
Ensembl ENSMUSG00000019122 ENSMUSG00000019122
UniProt P51670 P51670
mRNA序列 NM_011338 NM_011338
蛋白序列 NP_035468 NP_035468
基因位置 Chr 11:
83.57 – 83.58 Mb
Chr 11:
83.57 – 83.58 Mb
PubMed查询 [1] [2]

它由淋巴结相关上皮组织(FAE)分泌(如Peyer氏斑块英语Peyer's patch周围),并影响拥有细胞表面分子CD11b趋化因子受体CCR1树突状细胞[1]。 CCL9 通过其受体CCR1(破骨细胞中最丰富的趋化因子受体)激活破骨细胞,表明了CCL9可能在骨质吸收英语bone resorption中的重要作用[2]。CCL9巨噬细胞骨髓细胞里也持续表达[3][4]。编码CCL9的基因位于小鼠的11号染色体[4]

参考文献

  1. ^ Zhao X, Sato A, Dela Cruz C, Linehan M, Luegering A, Kucharzik T, Shirakawa A, Marquez G, Farber J, Williams I, Iwasaki A. CCL9 is secreted by the follicle-associated epithelium and recruits dome region Peyer's patch CD11b+ dendritic cells. J Immunol. 2003, 171 (6): 2797–803. PMID 12960300. 
  2. ^ Lean J, Murphy C, Fuller K, Chambers T. CCL9/MIP-1gamma and its receptor CCR1 are the major chemokine ligand/receptor species expressed by osteoclasts. J Cell Biochem. 2002, 87 (4): 386–93. PMID 12397598. doi:10.1002/jcb.10319. 
  3. ^ Youn B, Jang I, Broxmeyer H, Cooper S, Jenkins N, Gilbert D, Copeland N, Elick T, Fraser M, Kwon B. A novel chemokine, macrophage inflammatory protein-related protein-2, inhibits colony formation of bone marrow myeloid progenitors. J Immunol. 1995, 155 (5): 2661–7. PMID 7650394. 
  4. ^ 4.0 4.1 Hara T, Bacon K, Cho L, Yoshimura A, Morikawa Y, Copeland N, Gilbert D, Jenkins N, Schall T, Miyajima A. Molecular cloning and functional characterization of a novel member of the C-C chemokine family. J Immunol. 1995, 155 (11): 5352–8. PMID 7594550.