IL2RA

IL2RA
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1Z92、2B5I、2ERJ、3IU3、3NFP
識別號
别名	IL2RA；, CD25, IDDM10, IL2R, TCGFR, p55, IMD41, interleukin 2 receptor subunit alpha
外部ID	OMIM：147730 MGI：96549 HomoloGene：360 GeneCards：IL2RA
相關疾病
	類風濕性關節炎、1型糖尿病、多发性硬化症、克隆氏症、圓禿、type 1 diabetes mellitus 10、CD25 deficiency
基因位置（人类）
染色体	10號染色體
终止	6,062,370 bp
基因位置（小鼠）
染色体	小鼠2号染色体
终止	11,698,004 bp
RNA表达模式
	; ;
	查阅更多表达数据
基因本體
分子功能	• interleukin-2 receptor activity; • interleukin-2 binding; • 血浆蛋白结合;
細胞組分	• integral component of membrane; • 膜; • 细胞膜; • cell surface; • external side of plasma membrane; • 胞內; • interleukin-2 receptor complex;
生物學過程	• Notch信号通路; • positive regulation of T cell differentiation; • regulation of T cell tolerance induction; • inflammatory response to antigenic stimulus; • negative regulation of defense response to virus; • immune system process; • activation-induced cell death of T cells; • negative regulation of lymphocyte proliferation; • MAPK cascade; • T cell homeostasis; • regulation of T cell homeostatic proliferation; • cell surface receptor signaling pathway; • negative regulation of T cell proliferation; • negative regulation of immune response; • 免疫反应; • positive regulation of T cell proliferation; • 細胞增殖; • inflammatory response; • negative regulation of inflammatory response; • positive regulation of activated T cell proliferation; • 细胞凋亡; • regulation of regulatory T cell differentiation; • cytokine-mediated signaling pathway; • interleukin-2-mediated signaling pathway;
	Sources:Amigo / QuickGO
直系同源
	3559
	16184
	ENSG00000134460
	ENSMUSG00000026770
	P01589
	P01590
	NM_000417; NM_001308242; NM_001308243
	NM_008367
	NP_000408; NP_001295171; NP_001295172
	NP_032393
	維基數據
檢視/編輯人類	檢視/編輯小鼠

白介素-2受体α亚基（Interleukin-2 receptor subunit alpha，缩写IL2RA）也称为Tac抗原（Tac antigen）、P55、分化簇25（CD25，cluster of differentiation 25）是一种细胞表面蛋白质，由人类基因 IL2RA 编码^[6]，与β亚基（CD122）、γ亚基（CD132）共同组成白介素-2受体^[7]。

参考资料

^ 與IL2RA相關的疾病；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000134460 - Ensembl, May 2017
^ ^3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000026770 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Spolski R, Li P, Leonard WJ. Biology and regulation of IL-2: from molecular mechanisms to human therapy. Nature Reviews. Immunology. October 2018, 18 (10): 648–659. PMID 30089912. S2CID 51939991. doi:10.1038/s41577-018-0046-y.
^ Zhou P. Emerging mechanisms and applications of low-dose IL-2 therapy in autoimmunity. Cytokine & Growth Factor Reviews. October 2022, 67: 80–88. PMID 35803833. S2CID 250200065. doi:10.1016/j.cytogfr.2022.06.003.

外部链接

醫學主題詞表（MeSH）：Interleukin-2+Receptors

[1] 與IL2RA相關的疾病；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000134460 - Ensembl, May 2017

[refGRCm38Ensembl-3] 3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000026770 - Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[:1-6] Spolski R, Li P, Leonard WJ. Biology and regulation of IL-2: from molecular mechanisms to human therapy. Nature Reviews. Immunology. October 2018, 18 (10): 648–659. PMID 30089912. S2CID 51939991. doi:10.1038/s41577-018-0046-y.

[:5-7] Zhou P. Emerging mechanisms and applications of low-dose IL-2 therapy in autoimmunity. Cytokine & Growth Factor Reviews. October 2022, 67: 80–88. PMID 35803833. S2CID 250200065. doi:10.1016/j.cytogfr.2022.06.003.

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