HLA-C

HLA-C是人類白細胞抗原（HLA）的一个基因座，位于6号染色体上。成熟的HLA-C蛋白会与β2微球蛋白组成异二聚体，作为一个受体锚定在细胞表面。

Major histocompatibility complex, class I, C 主要组织相容性抗原复合物，第一类，C
Illustration of an HLA-C showing the HLA-B 'alpha' chain, ?2-Microglobulin, and the end of a peptide bound in the binding cleft.
有效结构 PDB 直系同源检索：PDBe, RCSB PDB查询代码列表 3BZF
标识
代号	HLA-C; D6S204; HLA-JY3; HLC-C; PSORS1
扩展标识	遗传学：142840 同源基因：133080 GeneCards: HLA-C Gene
基因本体论描述 分子功能 · MHC class I receptor activity 细胞成分 · Golgi membrane · extracellular region · plasma membrane · integral to plasma membrane · ER to Golgi transport vesicle membrane · phagocytic vesicle membrane · early endosome membrane · MHC class I protein complex · integral to lumenal side of endoplasmic reticulum membrane 生物过程 · antigen processing and presentation of peptide antigen via MHC class I · antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent · antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent · immune response · virus-host interaction · cytokine-mediated signaling pathway · antigen processing and presentation of exogenous peptide antigen via MHC class I · innate immune response · regulation of immune response · interferon-gamma-mediated signaling pathway · type I interferon-mediated signaling pathway Sources: Amigo / QuickGO
RNA表达模式
更多表达数据
直系同源体
物种	人类	小鼠
Entrez	3107	14964
Ensembl	ENSG00000204525	ENSMUSG00000073411
UniProt	P10321	P01899
mRNA序列	NM_001243042	NM_010380.3
蛋白序列	NP_001229971	NP_034510.3
基因位置	Chr 6: 31.24 – 31.24 Mb	Chr 17: 35.26 – 35.27 Mb
PubMed查询	[1]	[2]

延伸阅读

• Geyer M, Fackler OT, Peterlin BM. Structure--function relationships in HIV-1 Nef.. EMBO Rep. 2001, 2 (7): 580–5. PMC 1083955 . PMID 11463741. doi:10.1093/embo-reports/kve141. 
• Greenway AL, Holloway G, McPhee DA; et al. HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication.. J. Biosci. 2004, 28 (3): 323–35. PMID 12734410. doi:10.1007/BF02970151.  引文格式1维护：显式使用等标签 (link)
• Bénichou S, Benmerah A. [The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]. Med Sci (Paris). 2003, 19 (1): 100–6. PMID 12836198. doi:10.1051/medsci/2003191100. 
• Leavitt SA, SchOn A, Klein JC; et al. Interactions of HIV-1 proteins gp120 and Nef with cellular partners define a novel allosteric paradigm.. Curr. Protein Pept. Sci. 2004, 5 (1): 1–8. PMID 14965316. doi:10.2174/1389203043486955.  引文格式1维护：显式使用等标签 (link)
• Tolstrup M, Ostergaard L, Laursen AL; et al. HIV/SIV escape from immune surveillance: focus on Nef.. Curr. HIV Res. 2004, 2 (2): 141–51. PMID 15078178. doi:10.2174/1570162043484924.  引文格式1维护：显式使用等标签 (link)
• Joseph AM, Kumar M, Mitra D. Nef: "necessary and enforcing factor" in HIV infection.. Curr. HIV Res. 2005, 3 (1): 87–94. PMID 15638726. doi:10.2174/1570162052773013. 
• Anderson JL, Hope TJ. HIV accessory proteins and surviving the host cell.. Current HIV/AIDS reports. 2005, 1 (1): 47–53. PMID 16091223. doi:10.1007/s11904-004-0007-x. 

外部链接

• Molecular Anthropology Yahoo Group（页面存档备份，存于互联网档案馆）
• HLA Allele and Haplotype Frequency Database（页面存档备份，存于互联网档案馆）