Sp8轉錄因子

位於7號人類染色體的基因

Sp8轉錄因子又稱為特異性蛋白8(specificity protein 8、SP-8)或Btd轉錄因子[5]是由SP8基因編碼的人類蛋白質[6][7],位於人類的7號染色體中。Sp8是Sp/KLF家族轉錄因子

Sp8轉錄因子
識別號
别名SP8;, BTD, Sp8 transcription factor
外部IDOMIM608306 MGI2443471 HomoloGene18548 GeneCardsSP8
基因位置(人类
7號染色體
染色体7號染色體[1]
7號染色體
Sp8轉錄因子的基因位置
Sp8轉錄因子的基因位置
基因座7p21.1起始20,782,279 bp[1]
终止20,786,886 bp[1]
直系同源
物種人類小鼠
Entrez
Ensembl
UniProt
mRNA​序列

NM_182700
​NM_198956

NM_177082
​NM_001379379
​NM_001379380

蛋白序列

NP_874359
​NP_945194

NP_796056
​NP_001366308
​NP_001366309

基因位置​(UCSC)Chr 7: 20.78 – 20.79 MbChr 12: 118.81 – 118.82 Mb
PubMed​查找[3][4]
維基數據
檢視/編輯人類檢視/編輯小鼠

功能

Sp8在肢體生長早起扮演了協調的作用。[5]在小鼠實驗中,若小鼠缺失Sp8基因會導致嚴重的腦外畸形英语Exencephaly[8]

參考文獻

  1. ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000164651 - Ensembl, May 2017
  2. ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000048562 - Ensembl, May 2017
  3. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ 5.0 5.1 Treichel D, Schöck F, Jäckle H, Gruss P, Mansouri A. mBtd is required to maintain signaling during murine limb development (PDF). Genes & Development. November 2003, 17 (21): 2630–5 [2024-01-28]. PMC 280612 . PMID 14597661. doi:10.1101/gad.274103. (原始内容存档 (PDF)于2017-09-22). 
  6. ^ Bell SM, Schreiner CM, Waclaw RR, Campbell K, Potter SS, Scott WJ. Sp8 is crucial for limb outgrowth and neuropore closure. Proceedings of the National Academy of Sciences of the United States of America. October 2003, 100 (21): 12195–200. PMC 218735 . PMID 14526104. doi:10.1073/pnas.2134310100 . 
  7. ^ Entrez Gene: Sp8 transcription factor. 
  8. ^ Waclaw RR, Allen ZJ, Bell SM, Erdélyi F, Szabó G, Potter SS, Campbell K. The zinc finger transcription factor Sp8 regulates the generation and diversity of olfactory bulb interneurons. Neuron. February 2006, 49 (4): 503–16. PMID 16476661. S2CID 17734218. doi:10.1016/j.neuron.2006.01.018 . 

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