VUAA1
化合物
VUAA1是一种昆虫嗅觉共受体激动剂型驱虫剂[1][2]。由美国范德比尔特大学与比尔及梅琳达·盖茨基金会部分资助下发现[3][4]。
VUAA1 | |
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IUPAC名 N-(4-Ethylphenyl)-2-{[4-ethyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide | |
识别 | |
CAS号 | 525582-84-7 |
PubChem | 1319135 |
ChemSpider | 1105882 |
SMILES |
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性质 | |
化学式 | C19H21N5OS |
摩尔质量 | 367.47 g·mol−1 |
危险性 | |
GHS危险性符号 | |
GHS提示词 | Warning |
H-术语 | H315, H319, H335 |
P-术语 | P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362, P403+233, P405 |
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。 |
VUAA1被认为是通过强力刺激昆虫嗅觉受体来实现驱虫效果,且效力约为避蚊胺的1000倍[5],并可能导致“开创一个强大的新驱虫剂类型,用于消灭有害昆虫、农业害虫和病媒等的破坏行为”[6]。
VUAA1还展示出刺激蚊子精子活力的特性,从而表明蚊子的嗅觉和繁殖之间的联系[7]。
参考文献
- ^ Medicine, Vanderbilt University School of. Allosteric antagonism of insect odorant receptor ion channels. | Chemical Synthesis Core. medschool.vanderbilt.edu. [2016-06-02].
- ^ 向婧洁、钟延强、樊莉、鲁莹. 蚊虫驱避剂新进展. 中国媒介生物学及控制杂志. 2013, 24 (1): 79–82.
- ^ Jones, P. L.; Pask, G. M.; Rinker, D. C.; Zwiebel, L. J. Functional agonism of insect odorant receptor ion channels. Proceedings of the National Academy of Sciences. 2011, 108 (21): 8821–5. Bibcode:2011PNAS..108.8821J. PMC 3102409 . PMID 21555561. doi:10.1073/pnas.1102425108 .
- ^ Doug Gross. A bug repellent that could save lives - CNN.com. CNN. 5 May 2014 [2016-06-02].
- ^ New type of insect repellent may be thousands of times stronger than DEET (新闻稿). physorg.com. May 9, 2011.
- ^ Functional agonism of insect odorant receptor ion channel (PDF) (新闻稿). April 4, 2011.
- ^ VICB Article: Sulfilimine Cross-Links A Key to Tissue Evolution. www.vanderbilt.edu. [2016-06-02].