18-羥基-11-去氧皮質酮
化合物
18-羥基-11-去氧皮質酮（英語：18-Hydroxy-11-deoxycorticosterone，縮寫18-OH-DOC）是CYP450酶CYP11B3催化11-去氧皮質酮發生羥基化的產物，CYP11B3主要在大鼠新生兒的腎上腺表達[1][2]。
| 18-羥基-11-去氧皮質酮 | |
|---|---|
| |
| IUPAC名 (8R,9S,10R,13R,14S,17S)-17-(2-hydroxyacetyl)-13-(hydroxymethyl)-10-methyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one | |
| 別名 | 18,21-dihydroxy-4-pregnene-3,20-dione |
| 識別 | |
| CAS號 | 379-68-0 |
| PubChem | 64970 |
| ChemSpider | 58495 |
| SMILES |
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| MeSH | 18-hydroxydeoxycorticosterone |
| 性質 | |
| 化學式 | C21H30O4 |
| 摩爾質量 | 346.5 g·mol⁻¹ |
| 若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。 | |
參考文獻
- ^ Fujii S, Momoi K, Okamoto M, Yamano T, Okada T, Terasawa T. 18,19-Dihydroxydeoxycorticosterone, a new metabolite produced from 18-hydroxydeoxycorticosterone by cytochrome P-450(11) beta. Chemical synthesis and structural analysis by 1H NMR. Biochemistry. June 1984, 23 (12): 2558–64. PMID 6466598. doi:10.1021/bi00307a004.
- ^ Zhou MY, Gomez-Sanchez EP, Foecking MF, Gomez-Sanchez CE. Cloning and expression of the rat adrenal cytochrome P-450 11B3 (CYP11B3) enzyme cDNA: preferential 18-hydroxylation over 11 beta-hydroxylation of DOC. Molecular and Cellular Endocrinology. October 1995, 114 (1–2): 137–45. PMID 8674838. doi:10.1016/0303-7207(95)03653-o.