内皮唾液酸蛋白

内皮唾液酸蛋白
识别号
别名	CD248；, CD164L1, TEM1, CD248 molecule
外部ID	OMIM：606064 MGI：1917695 HomoloGene：10699 GeneCards：CD248
基因位置（人类）
染色体	11号染色体
终止	66,317,044 bp
基因位置（小鼠）
染色体	小鼠19号染色体
终止	5,120,710 bp
RNA表达模式
	查阅更多表达数据
基因本体
分子功能	• calcium ion binding; • extracellular matrix binding; • carbohydrate binding; • 分子功能; • extracellular matrix protein binding;
细胞组分	• 细胞质; • integral component of membrane; • 外排体; • 膜; • 细胞外间质; • external side of plasma membrane;
生物学过程	• positive regulation of endothelial cell apoptotic process; • 淋巴结的发生; • 细胞迁移; • positive regulation of cell population proliferation; • anatomical structure regression; • 生物过程;
	Sources:Amigo / QuickGO
直系同源
	57124
	70445
	ENSG00000174807
	ENSMUSG00000056481
	Q9HCU0
	Q91V98
	NM_020404
	NM_054042
	NP_065137
	NP_473383
	维基数据
查看/编辑人类	查看/编辑小鼠

内皮唾液酸蛋白（英语：Endosialin），也叫分化簇248、肿瘤内皮标志物1（Tumor Endothelial Marker 1），是人类中由CD248基因编码的蛋白质。^[5]^[6]^[7]

内皮唾液酸蛋白是C型凝集素跨膜受体家族中“第XIV组”的成员，不仅在细胞间粘附过程中发挥作用，而且在宿主防御中发挥作用。该组家族包括其他三个成员：CLEC14A、CD93和血栓调节蛋白，后者的特征更为明确。^[8]

内皮唾液酸蛋白的功能仍然难以捉摸，但其表达与胚胎和子宫中的血管生成以及肿瘤的发育和生长有关。^[9]

参见

分化群

参考资料

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000174807 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000056481 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW. Genes expressed in human tumor endothelium. Science. Aug 2000, 289 (5482): 1197–202. Bibcode:2000Sci...289.1197S. PMID 10947988. doi:10.1126/science.289.5482.1197.
^ Christian S, Ahorn H, Koehler A, Eisenhaber F, Rodi HP, Garin-Chesa P, Park JE, Rettig WJ, Lenter MC. Molecular cloning and characterization of endosialin, a C-type lectin-like cell surface receptor of tumor endothelium. J Biol Chem. May 2001, 276 (10): 7408–14. PMID 11084048. doi:10.1074/jbc.M009604200  .
^ Entrez Gene: CD248 CD248 molecule, endosialin. [2024-01-23]. （原始内容存档于2010-12-05）.
^ Khan KA, McMurray J, Mohammed FM, Bicknell R. C-type lectin domain group 14 proteins in vascular biology, cancer and inflammation.. FEBS Journal. 2019, 286 (17): 3299–3332. PMC 6852297  . PMID 31287944. doi:10.1111/febs.14985.
^ Rupp C, Dolznig H, Puri C, Sommergruber W, Kerjaschki D, Rettig WJ, Garin-Chesa P. Mouse endosialin, a C-type lectin-like cell surface receptor: expression during embryonic development and induction in experimental cancer neoangiogenesis.. Cancer Immun. 2006, 6: 10. PMID 16875435.

延伸阅读

Rettig WJ, Garin-Chesa P, Healey JH, et al. Identification of endosialin, a cell surface glycoprotein of vascular endothelial cells in human cancer.. Proc. Natl. Acad. Sci. U.S.A. 1992, 89 (22): 10832–6. Bibcode:1992PNAS...8910832R. PMC 50436  . PMID 1438285. doi:10.1073/pnas.89.22.10832  .
Opavsky R, Haviernik P, Jurkovicova D, et al. Molecular characterization of the mouse Tem1/endosialin gene regulated by cell density in vitro and expressed in normal tissues in vivo.. J. Biol. Chem. 2001, 276 (42): 38795–807. PMID 11489895. doi:10.1074/jbc.M105241200  .
Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241  . PMID 12477932. doi:10.1073/pnas.242603899  .
Ota T, Suzuki Y, Nishikawa T, et al. Complete sequencing and characterization of 21,243 full-length human cDNAs.. Nat. Genet. 2004, 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285  .
Gerhard DS, Wagner L, Feingold EA, et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928  . PMID 15489334. doi:10.1101/gr.2596504.
Brady J, Neal J, Sadakar N, Gasque P. Human endosialin (tumor endothelial marker 1) is abundantly expressed in highly malignant and invasive brain tumors.. J. Neuropathol. Exp. Neurol. 2005, 63 (12): 1274–83. PMID 15624764. doi:10.1093/jnen/63.12.1274  .
MacFadyen JR, Haworth O, Roberston D, et al. Endosialin (TEM1, CD248) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium. (PDF). FEBS Lett. 2005, 579 (12): 2569–75 [2024-01-23]. PMID 15862292. S2CID 11757246. doi:10.1016/j.febslet.2005.03.071  . （原始内容存档 (PDF)于2020-02-19）.
Dolznig H, Schweifer N, Puri C, et al. Characterization of cancer stroma markers: in silico analysis of an mRNA expression database for fibroblast activation protein and endosialin.. Cancer Immun. 2006, 5: 10. PMID 16076089.
Tomkowicz B, Rybinski K, Foley B, et al. Interaction of endosialin/TEM1 with extracellular matrix proteins mediates cell adhesion and migration.. Proc. Natl. Acad. Sci. U.S.A. 2008, 104 (46): 17965–70. PMC 2084280  . PMID 17986615. doi:10.1073/pnas.0705647104  .
Khan KA, McMurray J, Mohammed FM, Bicknell R. C-type lectin domain group 14 proteins in vascular biology, cancer and inflammation.. FEBS Journal. 2019, 286 (17): 3299–3332. PMC 6852297  . PMID 31287944. doi:10.1111/febs.14985.

外部链接

医学主题词表（MeSH）：CD248+protein,+human
Human CD248 genome location and CD248 gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.

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[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000174807 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000056481 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10947988-5] St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW. Genes expressed in human tumor endothelium. Science. Aug 2000, 289 (5482): 1197–202. Bibcode:2000Sci...289.1197S. PMID 10947988. doi:10.1126/science.289.5482.1197.

[pmid11084048-6] Christian S, Ahorn H, Koehler A, Eisenhaber F, Rodi HP, Garin-Chesa P, Park JE, Rettig WJ, Lenter MC. Molecular cloning and characterization of endosialin, a C-type lectin-like cell surface receptor of tumor endothelium. J Biol Chem. May 2001, 276 (10): 7408–14. PMID 11084048. doi:10.1074/jbc.M009604200  .

[entrez-7] Entrez Gene: CD248 CD248 molecule, endosialin. [2024-01-23]. （原始内容存档于2010-12-05）.

[8] Khan KA, McMurray J, Mohammed FM, Bicknell R. C-type lectin domain group 14 proteins in vascular biology, cancer and inflammation.. FEBS Journal. 2019, 286 (17): 3299–3332. PMC 6852297  . PMID 31287944. doi:10.1111/febs.14985.

[9] Rupp C, Dolznig H, Puri C, Sommergruber W, Kerjaschki D, Rettig WJ, Garin-Chesa P. Mouse endosialin, a C-type lectin-like cell surface receptor: expression during embryonic development and induction in experimental cancer neoangiogenesis.. Cancer Immun. 2006, 6: 10. PMID 16875435.

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