4-羟基雌酮
化合物
4-羟基雌酮（英语：4-Hydroxyestrone，缩写4-OHE1，或称为“雌甾-1,3,5(10)-三烯-3,4-二醇-17-酮”，estra-1,3,5(10)-trien-3,4-diol-17-one）是一种天然内源性的儿茶酚雌激素和雌酮与雌二醇的次要代谢产物[2][3][4]。它具有微量的雌激素活性，与2-羟基雌二醇、16α-羟基雌酮、雌三醇（16α-羟基雌二醇）和4-羟基雌二醇等其它羟基雌二醇类似，但不同于2-羟基雌酮[2][5]。
| 4-羟基雌酮 | |
|---|---|
| |
| IUPAC名 (8R,9S,13S,14S)-3,4-Dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one | |
| 别名 | 4-OHE1; Estra-1,3,5(10)-triene-3,4-diol-17-one; 3,4-Dihydroxyestra-1,3,5(10)-trien-17-one |
| 识别 | |
| CAS号 | 3131-23-5 
|
| PubChem | 9971251 |
| ChemSpider | 8146843 |
| SMILES |
|
| ChEBI | 87602 |
| 性质 | |
| 化学式 | C18H22O3 |
| 摩尔质量 | 286.37 g·mol−1 |
| 熔点 | 260—265 °C（533—538 K）[1] |
| 若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。 | |
参考资料
- ^ Jack Fishman, Maria Tomasz, Rosemarie Lehman. Catechol Derivatives of Estrogens 1. The Journal of Organic Chemistry. 1960-04, 25 (4): 585–588 [2021-01-27]. ISSN 0022-3263. doi:10.1021/jo01074a026 （英语）.
- ^ 2.0 2.1 Oettel M, Schillinger E. Estrogens and Antiestrogens I: Physiology and Mechanisms of Action of Estrogens and Antiestrogens. Springer Science & Business Media. 6 December 2012: 224, 232, 244–245, 249. ISBN 978-3-642-58616-3.
- ^ Rakel D. Integrative Medicine. Elsevier Health Sciences. 2012: 338–. ISBN 978-1-4377-1793-8.
- ^ Buchsbaum HJ. The Menopause. Springer Science & Business Media. 6 December 2012: 64–65. ISBN 978-1-4612-5525-3.
- ^ Bhavnani BR, Nisker JA, Martin J, Aletebi F, Watson L, Milne JK. Comparison of pharmacokinetics of a conjugated equine estrogen preparation (premarin) and a synthetic mixture of estrogens (C.E.S.) in postmenopausal women. Journal of the Society for Gynecologic Investigation. 2000, 7 (3): 175–83. PMID 10865186. doi:10.1016/s1071-5576(00)00049-6.