FK962

FK962
識別資訊
	IUPAC命名法 N-(1-acetylpiperidin-4-yl)-4-fluorobenzamide; ;
CAS號	283167-06-6
PubChem CID	9816738;
ChemSpider	7992488;
UNII	25J7VT36F9;
ChEMBL	ChEMBL4303387;
化學資訊
化學式	C14H17FN2O2
摩爾質量	264.30 g·mol−1
3D模型（JSmol（英語：JSmol））	交互式圖像;
	SMILES CC(=O)N1CCC(CC1)NC(=O)C2=CC=C(C=C2)F;
	InChI InChI=1S/C14H17FN2O2/c1-10(18)17-8-6-13(7-9-17)16-14(19)11-2-4-12(15)5-3-11/h2-5,13H,6-9H2,1H3,(H,16,19); Key:VBHVOHJOTMCSBQ-UHFFFAOYSA-N;

FK962是一種有機化合物，可用作體抑素釋放的促進劑。它可以刺激神經生長和神經突伸長，並已在動物模型中進行了研究，在阿茲海默症和視神經病變（英語：retinal neuropathy）等疾病的治療上具有潛在應用。^[1]^[2]^[3]^[4]

參考文獻

^ Tokita K, Inoue T, Yamazaki S, Wang F, Yamaji T, Matsuoka N, Mutoh S. FK962, a novel enhancer of somatostatin release, exerts cognitive-enhancing actions in rats. European Journal of Pharmacology. December 2005, 527 (1–3): 111–120. PMID 16325809. doi:10.1016/j.ejphar.2005.10.022.
^ McCarthy AD, Owens IJ, Bansal AT, McTighe SM, Bussey TJ, Saksida LM. FK962 and donepezil act synergistically to improve cognition in rats: potential as an add-on therapy for Alzheimer's disease. Pharmacology, Biochemistry, and Behavior. March 2011, 98 (1): 76–80. PMID 21130801. S2CID 26055819. doi:10.1016/j.pbb.2010.11.019.
^ Kishimoto Y, Yabuta C, Shearer TR, Azuma M. FK962 promotes neurite elongation and regeneration of cultured rat trigeminal ganglion cells: possible involvement of GDNF. Investigative Ophthalmology & Visual Science. August 2012, 53 (9): 5312–5319. PMID 22714891. doi:10.1167/iovs.11-8957.
^ Nakajima E, Walkup RD, Shearer TR, Azuma M. FK962 induces neurite outgrowth in cultured monkey trigeminal ganglion cells. Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie. January 2017, 255 (1): 107–112. PMID 27778122. S2CID 26043647. doi:10.1007/s00417-016-3525-5.

識別資訊

IUPAC命名法 N-(1-acetylpiperidin-4-yl)-4-fluorobenzamide
CAS號	283167-06-6 ^Y
PubChem CID	9816738
ChemSpider	7992488
UNII	25J7VT36F9
ChEMBL	ChEMBL4303387
化學資訊
化學式	C₁₄H₁₇FN₂O₂
摩爾質量	264.30 g·mol⁻¹
3D模型（JSmol（英語：JSmol））	交互式圖像
SMILES CC(=O)N1CCC(CC1)NC(=O)C2=CC=C(C=C2)F
InChI InChI=1S/C14H17FN2O2/c1-10(18)17-8-6-13(7-9-17)16-14(19)11-2-4-12(15)5-3-11/h2-5,13H,6-9H2,1H3,(H,16,19) Key:VBHVOHJOTMCSBQ-UHFFFAOYSA-N