核糖核酸酶Ⅲ

RNA酶III(Ribonuclease III,簡稱RNase III或RNase C[1]BRENDA英语BRENDA編號:3.1.26.3页面存档备份,存于互联网档案馆))為一類RNA酶,屬切割雙股RNA內切酶,均具有RNA酶III結構域[2]。此類RNA酶參與rRNASnRNASnoRNAmiRNA等RNA的生成過程[3],可在細胞中的特定位置切割這些RNA的前驅物以產生成熟的RNA[4][5]三域生物與部分病毒皆具有RNA酶III。

核糖核酸酶Ⅲ
RNA酶III與雙股RNA的交互作用
鑑定
標誌RNA酶III
PfamPF00636旧版
InterPro英语InterProIPR000999
PROSITE英语PROSITEPDOC00448
SCOP英语Structural Classification of Proteins1jfz / SUPFAM

RNA酶III可依結構域分為四型[6]。切割miRNA前驅物的DroshaDicer分別屬於三型與四型的RNA酶III[7][8]

參考文獻

  1. ^ Filippov, Valery; Solovyev, Victor; Filippova, Maria; Gill, Sarjeet S. A novel type of RNase III family proteins in eukaryotes. Gene. 7 March 2000, 245 (1): 213–221. PMID 10713462. doi:10.1016/S0378-1119(99)00571-5. 
  2. ^ Conrad, Christian; Rauhut, Reinhard. Ribonuclease III: new sense from nuisance. The International Journal of Biochemistry & Cell Biology. February 2002, 34 (2): 116–129. PMID 11809414. doi:10.1016/S1357-2725(01)00112-1. 
  3. ^ Zamore, Phollip D. Thirty-Three Years Later, a Glimpse at the Ribonuclease III Active Site. Molecular Cell. December 2001, 8 (6): 1158–1160. PMID 11885596. doi:10.1016/S1097-2765(01)00418-X . 
  4. ^ Inada, T.; Nakamura, Y. Lethal double-stranded RNA processing activity of ribonuclease III in the absence of SuhB protein of Escherichia coli. Biochimie. 1995, 77 (4): 294–302. PMID 8589060. doi:10.1016/0300-9084(96)88139-9. 
  5. ^ Park, Hongmarn; Yakhnin, Helen; Connolly, Michael; Romeo, Tony; Babitzke, Paul; Gourse, R. L. CsrA Participates in a PNPase Autoregulatory Mechanism by Selectively Repressing Translation of Transcripts That Have Been Previously Processed by RNase III and PNPase. Journal of Bacteriology. 15 December 2015, 197 (24): 3751–3759. PMC 4652041 . PMID 26438818. doi:10.1128/JB.00721-15. 
  6. ^ Liang YH, Lavoie M, Comeau MA, Abou Elela S, Ji X. Structure of a eukaryotic RNase III postcleavage complex reveals a double-ruler mechanism for substrate selection.. Mol Cell. 2014, 54 (3): 431–44. PMC 4019767 . PMID 24703949. doi:10.1016/j.molcel.2014.03.006. 
  7. ^ Filippov V, Solovyev V, Filippova M, Gill SS. A novel type of RNase III family proteins in eukaryotes. Gene. Mar 2000, 245 (1): 213–221. PMID 10713462. doi:10.1016/S0378-1119(99)00571-5. 
  8. ^ Bernstein E, Caudy AA, Hammond SM, Hannon GJ. Role for a bidentate ribonuclease in the initiation step of RNA interference.. Nature. 2001, 409 (6818): 363–6. PMID 11201747. doi:10.1038/35053110.