槟榔次碱

槟榔次碱是一种生物碱,存在于槟榔的果实中[3]。它是一种竞争性GABA摄取抑制剂。有研究称,青柠能够将槟榔碱水解成槟榔次碱[4]

槟榔次碱
IUPAC名
1-Methyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid
别名 Methylguvacine; Arecaine; N-Methylguvacine
识别
CAS号 499-04-7  checkY
PubChem 10355
ChemSpider 9928
SMILES
 
  • CN1CCC=C(C1)C(=O)O
InChI
 
  • 1/C7H11NO2/c1-8-4-2-3-6(5-8)7(9)10/h3H,2,4-5H2,1H3,(H,9,10)
InChIKey DNJFTXKSFAMXQF-UHFFFAOYAS
性质
化学式 C7H11NO2
摩尔质量 141.17 g·mol−1
熔点 232 °C(505 K)(分解)[1]
沸点 104~112 °C(14~16 torr)[2]
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

参考资料

  1. ^ "PhysProp" data were obtained from Syracuse Research Corporation of Syracuse, New York (US). Retrieved from SciFinder. [2021-08-15].
  2. ^ Berichte der Deutschen Chemischen Gesellschaft. Journal of the American Chemical Society. 1880-04, 2 (4) [2022-10-24]. ISSN 0002-7863. doi:10.1021/ja02135a601. (原始内容存档于2022-10-24) (英语). 
  3. ^ Voigt, Valerie; Laug, Linda; Zebisch, Katja; Thondorf, Iris; Markwardt, Fritz; Brandsch, Matthias. Transport of the areca nut alkaloid arecaidine by the human proton-coupled amino acid transporter 1 (hPAT1). Journal of Pharmacy and Pharmacology. 2013-03-12, 65 (4). ISSN 0022-3573. PMID 23488788. doi:10.1111/jphp.12006 (英语). 
  4. ^ Johnston, G. A. R.; Krogsgaard-Larsen, P.; Stephanson, A. Betel nut constituents as inhibitors of γ-aminobutyric acid uptake. Nature. 1975-12, 258 (5536) [2022-10-24]. Bibcode:1975Natur.258..627J. ISSN 0028-0836. PMID 1207742. doi:10.1038/258627a0. (原始内容存档于2022-10-24) (英语).