糖磷脂酰肌醇
糖磷脂酰肌醇(英語:Glycosylphosphatidylinositol,ⓘ),或 glycophosphatidylinositol,糖基磷脂酰肌醇,缩写 GPI)是一个短链糖脂,可以连接到蛋白质的C端,作为一种轉译后修饰。含有GPI的蛋白质可以锚定在细胞膜上,在各种各样的生物过程中发挥关键作用。[1] 它是通过磷脂酰肌醇基团与糖连接,再通过磷酸乙醇胺(EtNP)桥接到蛋白质C端的氨基酸残基上。两个疏水性磷脂酰脂肪酸长链用于锚定到细胞膜中。
GPI synthesis components | |
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鑑定 | |
標誌 | GPI |
膜蛋白數據庫 | 327 |
参考文献
- ^ Paulick, Margot G.; Bertozzi, Carolyn R. The Glycosylphosphatidylinositol Anchor: A Complex Membrane-Anchoring Structure for Proteins. Biochemistry. 2008-07-08, 47 (27): 6991–7000. ISSN 0006-2960. PMC 2663890 . PMID 18557633. doi:10.1021/bi8006324.
外部链接
- 醫學主題詞表(MeSH):Glycosylphosphatidylinositols(美式英语)
- https://web.archive.org/web/20150902103838/https://upload.wikimedia.org/wikibooks/en/thumb/7/7c/GPI-Anchor.jpg/180px-GPI-Anchor.jpg
- http://www.sigmaaldrich.com/life-science/proteomics/post-translational-analysis/glycosylation/structures-symbols/gpi-anchor-structure.html (页面存档备份,存于互联网档案馆)