高丝氨酸脱氢酶
高丝氨酸脱氢酶（英語：homoserine dehydrogenase，EC 1.1.1.3 （页面存档备份，存于互联网档案馆））是一种以NAD+或NADP+为受体、作用于供体CH-OH基团上的氧化还原酶。这种酶能催化以下酶促反应：
| 高丝氨酸脱氢酶 | |||||||
|---|---|---|---|---|---|---|---|
| |||||||
| 结合了NAD类似物和L-高丝氨酸的高丝氨酸脱氢酶复合物 | |||||||
| |||||||
| 识别码 | |||||||
| EC編號 | 1.1.1.3 | ||||||
| CAS号 | 9028-13-1 | ||||||
| 数据库 | |||||||
| IntEnz | IntEnz浏览 | ||||||
| BRENDA | BRENDA入口 | ||||||
| ExPASy | NiceZyme浏览 | ||||||
| KEGG | KEGG入口 | ||||||
| MetaCyc | 代谢路径 | ||||||
| PRIAM | 概述 | ||||||
| PDB | RCSB PDB PDBj PDBe PDBsum | ||||||
| 基因本体 | AmiGO / EGO | ||||||
| |||||||
高丝氨酸脱氢酶参与甘氨酸、丝氨酸和苏氨酸的代谢以及赖氨酸的生物合成。高丝氨酸脱氢酶参与天冬氨酸途径的第三步反应，在NAD或NADP的参与下将天冬氨酸半醛还原为高丝氨酸。[1][2]
参考文献
- ^ Thomas D, Barbey R, Surdin-Kerjan Y. Evolutionary relationships between yeast and bacterial homoserine dehydrogenases. FEBS Lett. June 1993, 323 (3): 289–93. PMID 8500624. doi:10.1016/0014-5793(93)81359-8.
- ^ Cami B, Clepet C, Patte JC. Evolutionary comparisons of three enzymes of the threonine biosynthetic pathway among several microbial species. Biochimie. 1993, 75 (6): 487–95. PMID 8395899.
- BLACK S, WRIGHT NG. Homoserine dehydrogenase. J. Biol. Chem. 1955, 213 (1): 51–60. PMID 14353905.
- Starnes WL, Munk P, Maul SB, Cunningham GN, Cox DJ, Shive W. Threonine-sensitive aspartokinase-homoserine dehydrogenase complex, amino acid composition, molecular weight, and subunit composition of the complex. Biochemistry. 1972, 11 (5): 677–87. PMID 4551091. doi:10.1021/bi00755a003.
- Veron M, Falcoz-Kelly F, Cohen GN. The threonine-sensitive homoserine dehydrogenase and aspartokinase activities of Escherichia coli K12. The two catalytic activities are carried by two independent regions of the polypeptide chain. Eur. J. Biochem. 1972, 28 (4): 520–7. PMID 4562990. doi:10.1111/j.1432-1033.1972.tb01939.x.