18-羟基-11-脱氧皮质酮

化合物

18-羟基-11-脱氧皮质酮(英語:18-Hydroxy-11-deoxycorticosterone,缩写18-OH-DOC)是CYP450CYP11B3催化11-脱氧皮质酮发生羟基化的产物,CYP11B3主要在大鼠新生儿肾上腺表达[1][2]

18-羟基-11-脱氧皮质酮
IUPAC名
(8R,9S,10R,13R,14S,17S)-17-(2-hydroxyacetyl)-13-(hydroxymethyl)-10-methyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
别名 18,21-dihydroxy-4-pregnene-3,20-dione
识别
CAS号 379-68-0
PubChem 64970
ChemSpider 58495
SMILES
 
  • C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@H]4C(=O)CO)CO
MeSH 18-hydroxydeoxycorticosterone
性质
化学式 C21H30O4
摩尔质量 346.5 g·mol⁻¹
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

参考文献

  1. ^ Fujii S, Momoi K, Okamoto M, Yamano T, Okada T, Terasawa T. 18,19-Dihydroxydeoxycorticosterone, a new metabolite produced from 18-hydroxydeoxycorticosterone by cytochrome P-450(11) beta. Chemical synthesis and structural analysis by 1H NMR. Biochemistry. June 1984, 23 (12): 2558–64. PMID 6466598. doi:10.1021/bi00307a004. 
  2. ^ Zhou MY, Gomez-Sanchez EP, Foecking MF, Gomez-Sanchez CE. Cloning and expression of the rat adrenal cytochrome P-450 11B3 (CYP11B3) enzyme cDNA: preferential 18-hydroxylation over 11 beta-hydroxylation of DOC. Molecular and Cellular Endocrinology. October 1995, 114 (1–2): 137–45. PMID 8674838. doi:10.1016/0303-7207(95)03653-o. 

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