2-苄基哌啶
化合物
2-苄基哌啶(英语:2-Benzylpiperidine)是哌啶类的兴奋剂药物。它在结构上与哌甲酯和2-二苯甲基哌啶等其他药物相似,但效力大约是其二十分之一。虽然它能将去甲肾上腺素水平提高到与右旋苯丙胺大致相同的程度,[1]但它对多巴胺水平的影响非常小,其对多巴胺转运蛋白的结合亲和力比去甲肾上腺素转运蛋白低约175倍。[2]2-苄基哌啶很少用作兴奋剂,它主要用作制造其他药物的合成中间体。[3][4][5]
臨床資料 | |
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给药途径 | 口服 |
ATC碼 |
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法律規範狀態 | |
法律規範 |
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识别信息 | |
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CAS号 | 32838-55-4 |
PubChem CID | |
ChemSpider | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.046.581 |
化学信息 | |
化学式 | C12H17N |
摩尔质量 | 175.28 g·mol−1 |
3D模型(JSmol) | |
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参见
参考资料
- ^ Ferris RM, Tang FL. Comparison of the effects of the isomers of amphetamine, methylphenidate and deoxypipradrol on the uptake of l-[3H]norepinephrine and [3H]dopamine by synaptic vesicles from rat whole brain, striatum and hypothalamus. The Journal of Pharmacology and Experimental Therapeutics. September 1979, 210 (3): 422–8. PMID 39160.
- ^ Kim DI, Deutsch HM, Ye X, Schweri MM. Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate. Journal of Medicinal Chemistry. May 2007, 50 (11): 2718–31. PMID 17489581. doi:10.1021/jm061354p.
- ^ Ablordeppey SY, Fischer JB, Law H, Glennon RA. Probing the proposed phenyl-A region of the sigma-1 receptor. Bioorganic & Medicinal Chemistry. August 2002, 10 (8): 2759–65. PMID 12057665. doi:10.1016/S0968-0896(02)00096-2.
- ^ Ágai B, Proszenyák A, Tárkányi G, Vida L, Faigl F. Convenient, Benign and Scalable Synthesis of 2- and 4-Substituted Benzylpiperidines.. European Journal of Organic Chemistry. 2004, 2004 (17): 3623–3632. doi:10.1002/ejoc.200400215.
- ^ US 6124317,Bigge CF, Keana JR, Cai SX, Weber E, Woodward R, Lan NC, Guzikowski AP,「2-substituted piperidine analogs and their use as subtype-selective NMDA receptor antagonists.」