2-苄基哌啶

2-苄基哌啶
臨床資料
給藥途徑	口服
ATC碼	未分配;
法律規範狀態
法律規範	不受控制;
識別資訊
	IUPAC命名法 2-benzylpiperidine; ;
CAS號	32838-55-4
PubChem CID	118004;
ChemSpider	105447 ;
CompTox Dashboard（英語：CompTox Chemicals Dashboard） (EPA)	DTXSID40871372 ;
ECHA InfoCard	100.046.581
化學資訊
化學式	C12H17N
摩爾質量	175.28 g·mol−1
3D模型（JSmol（英語：JSmol））	交互式圖像;
	SMILES C1CCNC(C1)CC2=CC=CC=C2;
	InChI InChI=1S/C12H17N/c1-2-6-11(7-3-1)10-12-8-4-5-9-13-12/h1-3,6-7,12-13H,4-5,8-10H2 ; Key:ITXCORRITGNIHP-UHFFFAOYSA-N ;

2-苄基哌啶（英語：2-Benzylpiperidine）是哌啶類的興奮劑藥物。它在結構上與哌甲酯和2-二苯甲基哌啶等其他藥物相似，但效力大約是其二十分之一。雖然它能將去甲腎上腺素水平提高到與右旋苯丙胺大致相同的程度，^[1]但它對多巴胺水平的影響非常小，其對多巴胺轉運蛋白的結合親和力比去甲腎上腺素轉運蛋白低約175倍。^[2]2-苄基哌啶很少用作興奮劑，它主要用作製造其他藥物的合成中間體。^[3]^[4]^[5]

參見

^ Ferris RM, Tang FL. Comparison of the effects of the isomers of amphetamine, methylphenidate and deoxypipradrol on the uptake of l-[3H]norepinephrine and [3H]dopamine by synaptic vesicles from rat whole brain, striatum and hypothalamus. The Journal of Pharmacology and Experimental Therapeutics. September 1979, 210 (3): 422–8. PMID 39160.
^ Kim DI, Deutsch HM, Ye X, Schweri MM. Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate. Journal of Medicinal Chemistry. May 2007, 50 (11): 2718–31. PMID 17489581. doi:10.1021/jm061354p.
^ Ablordeppey SY, Fischer JB, Law H, Glennon RA. Probing the proposed phenyl-A region of the sigma-1 receptor. Bioorganic & Medicinal Chemistry. August 2002, 10 (8): 2759–65. PMID 12057665. doi:10.1016/S0968-0896(02)00096-2.
^ Ágai B, Proszenyák A, Tárkányi G, Vida L, Faigl F. Convenient, Benign and Scalable Synthesis of 2- and 4-Substituted Benzylpiperidines.. European Journal of Organic Chemistry. 2004, 2004 (17): 3623–3632. doi:10.1002/ejoc.200400215.
^ US 6124317,Bigge CF, Keana JR, Cai SX, Weber E, Woodward R, Lan NC, Guzikowski AP,「2-substituted piperidine analogs and their use as subtype-selective NMDA receptor antagonists.」