利凡斯的明

化合物

利凡斯的明(英语:Rivastigmine,商品名:忆思能,Exelon等)是一种含氮有机化合物,分子式C14H22N2O2,属于胆碱酯酶抑制剂,用于治疗轻度至中度阿兹海默症[4]

利凡斯的明
临床资料
商品名英语Drug nomenclatureExelon, Prometax, others
AHFS/Drugs.comMonograph
MedlinePlusa602009
核准状况
怀孕分级
给药途径By mouth, transdermal patch
ATC码
法律规范状态
法律规范
药物动力学数据
生物利用度60 to 72%
血浆蛋白结合率40%
药物代谢Liver, via pseudocholinesterase
生物半衰期1.5 hours
排泄途径97% in urine
识别信息
  • (S)-3-[1-(dimethylamino)ethyl]phenyl N-ethyl-N-methylcarbamate
CAS号123441-03-2  checkY
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.120.679 编辑维基数据链接
化学信息
化学式C14H22N2O2
摩尔质量250.34 g·mol−1
3D模型(JSmol英语JSmol
  • O=C(Oc1cc(ccc1)[C@@H](N(C)C)C)N(CC)C
  • InChI=1S/C14H22N2O2/c1-6-16(5)14(17)18-13-9-7-8-12(10-13)11(2)15(3)4/h7-11H,6H2,1-5H3/t11-/m0/s1 checkY
  • Key:XSVMFMHYUFZWBK-NSHDSACASA-N checkY

参考文献

  1. ^ Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017. Therapeutic Goods Administration (TGA). 21 June 2022 [30 March 2024]. 
  2. ^ Product monograph brand safety updates. Health Canada. 7 July 2016 [1 April 2024]. 
  3. ^ Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control]. Diário Oficial da União. 2023-03-31 (2023-04-04) [2023-08-16]. (原始内容存档于2023-08-03) (巴西葡萄牙语). 
  4. ^ Khoury R, Rajamanickam J, Grossberg GT. An update on the safety of current therapies for Alzheimer's disease: focus on rivastigmine. Therapeutic Advances in Drug Safety (SAGE Publications). March 2018, 9 (3): 171–178. PMC 5810854 . PMID 29492246. doi:10.1177/2042098617750555. 

外部链接