苹果酸脱氢酶 (草酰乙酸脱羧) (NADP+)

苹果酸脱氢酶 (草酰乙酸脱羧) (NADP⁺)（英语：malate dehydrogenase (oxaloacetate-decarboxylating) (NADP⁺)，EC 1.1.1.40 （页面存档备份，存于互联网档案馆））是一种以NAD⁺或NADP⁺为受体、作用于供体CH-OH基团上的氧化还原酶。这种酶能催化以下酶促反应：

苹果酸脱氢酶 (草酰乙酸脱羧) (NADP+)
苹果酸脱氢酶 (草酰乙酸脱羧) (NADP+)的结构（PDB 2AW5）
命名 系统命名 (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating) 缩写 别名 'malic' enzyme; pyruvic-malic carboxylase; malate dehydrogenase (decarboxylating, NADP); NADP-linked decarboxylating malic enzyme; NADP-malic enzyme; NADP-specific malic enzyme; NADP-specific malate dehydrogenase; malate dehydrogenase (NADP, decarboxylating); L-malate:NADP oxidoreductase; malate dehydrogenase (oxaloacetate-decarboxylating) (NADP)
识别码
EC编号	1.1.1.40
CAS号	9028-47-1
数据库
IntEnz	IntEnz浏览
BRENDA	BRENDA入口
ExPASy	NiceZyme浏览
KEGG	KEGG入口
MetaCyc	代谢路径
PRIAM	概述
PDB	RCSB PDB PDBj PDBe PDBsum
基因本体	AmiGO / EGO
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(S)-苹果酸 + NADP⁺ $\rightleftharpoons$ 丙酮酸 + CO₂ + NADPH

苹果酸脱氢酶 (草酰乙酸脱羧) (NADP⁺)是C₄和CAM植物固定二氧化碳过程中使用的三种脱羧酶之一（其余两种分别为苹果酸脱氢酶 (脱羧)和磷酸烯醇丙酮酸羧化激酶）。

参考文献

• Harary, I., Korey, S.R. and Ochoa, S. Biosynthesis of dicarboxylic acids by carbon dioxide fixation. VII Equilibrium of malic enzyme reaction. J. Biol. Chem. 1953, 203 (2): 595–604. PMID 13084629. 
• Ochoa S, Mehler AH and Kornberg A. Biosynthesis of dicarboxylic acids by carbon dioxide fixation. I Isolation and properties of an enzyme from pigeon liver catalyzing the reversible oxidative decarboxylation of l-malic acid. J. Biol. Chem. 1948, 174: 979–1000. 
• RUTTER WJ, LARDY HA. Purification and properties of pigeon liver malic enzyme. J. Biol. Chem. 1958, 233 (2): 374–82. PMID 13563505. 
• Strickland RG. Some properties of the malic enzyme of pigeon liver. 1. Conversion of malate into pyruvate. Biochem. J. 1959, 73: 646–654. 
• Strickland RG. Some properties of the malic enzyme of pigeon liver. 2. Synthesis of malate from pyruvate. Biochem. J. 1959, 73: 654–659. PMC 1197116 . PMID 13834657. 
• Walker DA. Physiological studies on acid metabolism. 7. Malic enzyme from Kalanchoe crenata: effects of carbon dioxide concentration. Biochem. J. 1960, 74: 216–223. PMC 1204145 . PMID 13842495.