2-(3,3-二苯基丙基)咪唑-5-乙胺
化合物
2-(3,3-二苯基丙基)咪唑-5-乙胺一类强效且具有选择性的组胺H1受体激动剂的母体化合物[1]，化学式为C20H23N3，它可以二苯甲烷为原料，经多步反应制得。[2]
| 2-(3,3-二苯基丙基)咪唑-5-乙胺 | |
|---|---|
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| 别名 | 二苯丙基组胺（Histaprodifen） 2-(3,3-二苯基丙基)组胺 |
| 识别 | |
| CAS号 | 222545-59-7 
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| 性质 | |
| 化学式 | C20H23N3 |
| 摩尔质量 | 305.42 g·mol−1 |
| 若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。 | |
它和4-吡啶乙酸盐酸盐在吡啶和CDI的存在下于THF中反应，可以得到N-[2-(3,3-二苯基丙基)咪唑-5-基乙基]-4-吡啶乙酰胺。[3]
参考文献
- ^ Sigurd Elz, Kai Kramer, Christian Leschke, Walter Schunack. Ring-substituted histaprodifen analogues as partial agonists for histamine H1 receptors: synthesis and structure–activity relationships. European Journal of Medicinal Chemistry, 2000. 35 (1): 41-52. doi:10.1016/S0223-5234(00)00105-7.
- ^ Elz S, Kramer K, Pertz HH; et al. Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H1-receptor agonists. J. Med. Chem. 2000, 43 (6): 1071–1084. PMID 10737740.
- ^ Sonja Menghin, Heinz H. Pertz, Kai Kramer, Roland Seifert, Walter Schunack, and Sigurd Elz. Nα-Imidazolylalkyl and Pyridylalkyl Derivatives of Histaprodifen: Synthesis and in Vitro Evaluation of Highly Potent Histamine H1-Receptor Agonists. J. Med. Chem. 2003, 46, 25, 5458–5470. doi:10.1021/jm0309147.