D-15414,分子式C17H17NO2,是2-苯基吲哚非甾体药物,具有弱的雌激素效应,从未上市[1],也是选择性雌激素受体调节物(SERM)秦哚昔芬(D-16726)在体内的主要代谢产物[2]

D-15414
识别信息
  • 1-ethyl-2-(4-hydroxyphenyl)-3-methylindol-5-ol
CAS号86111-11-7  checkY
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C17H17NO2
摩尔质量267.33 g·mol−1
3D模型(JSmol英语JSmol
  • CCN1C2=C(C=C(C=C2)O)C(=C1C3=CC=C(C=C3)O)C
  • InChI=1S/C17H17NO2/c1-3-18-16-9-8-14(20)10-15(16)11(2)17(18)12-4-6-13(19)7-5-12/h4-10,19-20H,3H2,1-2H3
  • Key:BXTNOIWYTWIPEL-UHFFFAOYSA-N

参考文献

  1. ^ Jordan VC, Tormey DC. Antiestrogen therapy for breast cancer: current strategies and future prospects. Cancer Treatment and Research. 1988, 39: 97–110. ISBN 978-1-4612-8974-6. PMID 2908611. doi:10.1007/978-1-4613-1731-9_7. 
  2. ^ von Angerer E, Prekajac J, Berger M. The inhibitory effect of 5-acetoxy-2-(4-acetoxyphenyl)-1-ethyl-3-methylindole (D 16726) on estrogen-dependent mammary tumors. European Journal of Cancer & Clinical Oncology. April 1985, 21 (4): 531–537. PMID 3924626. doi:10.1016/0277-5379(85)90048-3. 

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