D75-4590

化合物

D75-4590是一种含氮有机化合物,分子式C21H27N5,属于吡多苯并咪唾衍生物,可作为抗真菌药,抑制真菌的β-葡聚糖生物合成[1][2]

D75-4590
IUPAC名
1[2-(Diethylamino)ethyl]amino2-ethyl-3-methylpyrido[1,2-a]benzimidazole-4-carbonitrile
别名 4-[2-(Diethylamino)ethylamino]-3-ethyl-2-methyl-4a,9-diaza-3,4-dihydrofluorene-1-carbonitrile
识别
CAS号 384376-42-5  ☒N
PubChem 948175
ChemSpider 824252
SMILES
 
  • CCc1c(c(c2nc3ccccc3n2c1NCCN(CC)CC)C#N)C
性质
化学式 C21H27N5
摩尔质量 349.473 g/mol g·mol⁻¹
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

参考文献

  1. ^ Kitamura, Akihiro; Someya, Kazuhiko; Hata, Masato; Nakajima, Ryohei; Takemura, Makoto. Discovery of a Small-Molecule Inhibitor of β-1,6-Glucan Synthesis. Antimicrobial Agents and Chemotherapy. 2008, 53 (2): 670–7. PMC 2630612 . PMID 19015325. doi:10.1128/AAC.00844-08. 
  2. ^ Kitamura, Akihiro; Someya, Kazuhiko; Okumura, Ryo; Hata, Masato; Takeshita, Hiroshi; Nakajima, Ryohei. In Vitro Antifungal Activities of D11-2040, a β-1,6-Glucan Inhibitor, with or without Currently Available Antifungal Drugs. Biological & Pharmaceutical Bulletin. 2010, 33 (2): 192–7. PMID 20118539. doi:10.1248/bpb.33.192 . 

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