MYO1F

位於19號人類染色體的基因

MYO1F是一个位于人类17号染色体上的基因,该编码是一种隶属于肌凝蛋白超家族的蛋白肌凝蛋白-If(Myosin-If)。MYO1F编码的肌凝蛋白-If是一种非典型的肌凝蛋白,与编码肌凝蛋白-1MYH1是两种不同的基因。[5][6][7][8]

MYO1F
识别号
别名MYO1F;, myosin IF
外部IDOMIM601480 MGI107711 HomoloGene56276 GeneCardsMYO1F
基因位置(人类
19号染色体
染色体19号染色体[1]
19号染色体
MYO1F的基因位置
MYO1F的基因位置
基因座19p13.2起始8,520,778 bp[1]
终止8,577,577 bp[1]
RNA表达模式
查阅更多表达数据
直系同源
物种人类小鼠
Entrez
Ensembl
UniProt
mRNA​序列

​NM_012335
​NM_001348355

NM_053214

蛋白序列

NP_036467
​NP_001335284

无数据

基因位置​(UCSC)Chr 19: 8.52 – 8.58 MbChr 17: 33.77 – 33.83 Mb
PubMed​查找[3][4]
维基数据
查看/编辑人类查看/编辑小鼠

MYO1F基因主要在免疫系统中表达,其功能主要与细胞黏附,细胞移动有关[9]。而该基因的突变则与非综合征性耳聋有关[10]

参见

参考资料

  1. ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000142347 - Ensembl, May 2017
  2. ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000024300 - Ensembl, May 2017
  3. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ MYO1F Gene. GeneCards. [2021-05-02]. (原始内容存档于2021-06-04). 
  6. ^ Crozet F, el Amraoui A, Blanchard S, Lenoir M, Ripoll C, Vago P, Hamel C, Fizames C, Levi-Acobas F, Depetris D, Mattei MG, Weil D, Pujol R, Petit C. Cloning of the genes encoding two murine and human cochlear unconventional type I myosins. Genomics. Apr 1997, 40 (2): 332–41. PMID 9119401. doi:10.1006/geno.1996.4526. 
  7. ^ Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, Anderson BL, Sherr EH, Chen ZY, Greene LA, Ward DC, Corey DP, Mooseker MS, Copeland NG, Jenkins NA. Mapping of unconventional myosins in mouse and human. Genomics. Feb 1997, 36 (3): 431–9. PMID 8884266. doi:10.1006/geno.1996.0488. 
  8. ^ Entrez Gene: MYO1F myosin IF. [2021-05-02]. (原始内容存档于2010-12-05). 
  9. ^ Kim SV, Mehal WZ, Dong X, Heinrich V, Pypaert M, Mellman I, Dembo M, Mooseker MS, Wu D, Flavell RA. Modulation of cell adhesion and motility in the immune system by Myo1f. Science. October 2006, 314 (5796): 136–9. PMID 17023661. doi:10.1126/science.1131920. 
  10. ^ Chen AH, Stephan DA, Hasson T, Fukushima K, Nelissen CM, Chen AF, Jun AI, Ramesh A, Van Camp G, Smith RJ. MYO1F as a candidate gene for nonsyndromic deafness, DFNB15. Arch. Otolaryngol. Head Neck Surg. August 2001, 127 (8): 921–5. PMID 11493199. doi:10.1001/archotol.127.8.921. 

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