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免疫复合体，有些时候又称做抗原-抗体复合物，是一种由抗体完整连结到可溶性抗原所组成的分子。[1]抗体及抗原之间的连结作为单元性的物件。and antibody act as a unitary object, effectively an antigen of its own with a specific epitope. After an antigen-antibody reaction, the immune complexes can be subject to any of a number of responses, including complement deposition, opsonization,[2] phagocytosis, or processing by proteases. Red blood cells carrying CR1-receptors on their surface may bind C3b-coated immune complexes and transport them to phagocytes, mostly in liver and spleen, and return to the general circulation.
Immune complexes may themselves cause illness when they are deposited in organs, for example, in certain forms of vasculitis. This is the third form of hypersensitivity in the Gell-Coombs classification, called type III hypersensitivity.[3] Such hypersensitivity progressing to disease states produces the immune complex diseases.
Immune complex deposition is a prominent feature of several autoimmune diseases, including systemic lupus erythematosus, cryoglobulinemia, rheumatoid arthritis, scleroderma and Sjögren's syndrome.[4][5]
References
- ^ Cush, John; Kavanaugh, Arthur; Stein, Charles. Rheumatology: Diagnosis and Therapeutics. Lippincott Williams & Wilkins. 2005: 78. ISBN 9780781757324.
- ^ Goldsby, Richard. Immunology. Macmillan. 2002: 381. ISBN 9780716749479.
- ^ Barret, James. Basic Immunology and its Medical Application 2. St.Louis: The C.V. Mosby Company. 1980. ISBN 0-8016-0495-8.
- ^ Lawley, Thomas; Moustopoulos, Haralampos. Demonstration of Circulating Immune Complexes in Sjögren's Syndrome. Journal of Immunology (The American Association of Immunologists). 1979, 123 (3): 1382–7. PMID 469255.
- ^ Wallace, Daniel (编). The New Sjogren's Syndrome Handbook. Oxford University Press. 2004: 68. ISBN 9780198038481.
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