去甲肾上腺素转运体

位於16號人類染色體的基因

去甲肾上腺素转运体(英语:Norepinephrine_transporterNET),也被称为溶质载体家族6成员2(英语:solute carrier family 6 member 2SLC6A2),是由SLC6A2基因编码的蛋白质[6]。NET是一种单胺转运体英语monoamine transporter,负责依赖Na+/Cl的胞外去甲肾上腺素再摄取。NET也可转运多巴胺。对这两种神经递质的再吸收是调控突触间隙英语synaptic cleft传导物浓度的重要机制。

去甲肾上腺素转运体
识别号
别名SLC6A2;, NAT1, NET, NET1, SLC6A5, solute carrier family 6 member 2, Norepinephrine transporter, norepinephrine transporter gene
外部IDOMIM163970 MGI1270850 HomoloGene816 GeneCardsSLC6A2
为以下药物的标靶
阿米替林、​阿莫沙平、​阿托莫西汀、​丁氨苯丙酮、​西酞普兰、​氯米帕明、​地昔帕明、​去甲文拉法辛、​右旋安非他命、​度洛西汀、​丙咪嗪、​左旋米那普伦、​洛非帕明、​马普替林、​马吲哚、​哌甲酯、​奈法唑酮、​nisoxetine、​(RS)-nomifensine、​去甲替林、​苯乙肼、​普罗替林、​喹硫平、​𫫇泼西汀、​西布曲明、​他喷他窦、​曲米帕明、​文拉法辛、​zotepine、​serdexmethylphenidate chloride、​右旋哌甲酯、​右旋安非他命、​苯丙胺、​liafensine、​甲基苯丙胺、​phentermine hydrochloride、​安非拉酮、​去甲文拉法辛、​马吲哚、​伪麻黄碱、​methylphenidate hydrochloride、​dasotraline、​milnacipran、​diethylpropion hydrochloride、​bretylium tosylate、​desipramine hydrochloride、​guanadrel sulfate、​imipramine hydrochloride、​nefazodone hydrochloride、​orphenadrine citrate、​phenmetrazine hydrochloride、​protriptyline hydrochloride、​(+)-pseudoephedrine hydrochloride、​venlafaxine hydrochloride[1]
基因位置(人类
16号染色体
染色体16号染色体[2]
16号染色体
去甲肾上腺素转运体的基因位置
去甲肾上腺素转运体的基因位置
基因座16q12.2起始55,655,988 bp[2]
终止55,707,645 bp[2]
RNA表达模式




查阅更多表达数据
直系同源
物种人类小鼠
Entrez
Ensembl
UniProt
mRNA​序列

NM_001043
​NM_001172501
​NM_001172502
​NM_001172504

NM_009209

蛋白序列

NP_001034
​NP_001165972
​NP_001165973
​NP_001165975

NP_033235

基因位置​(UCSC)Chr 16: 55.66 – 55.71 MbChr 8: 93.69 – 93.73 Mb
PubMed​查找[4][5]
维基数据
查看/编辑人类查看/编辑小鼠

NET以及其他单胺转运体是不少抗抑郁剂以及娱乐性药物的作用对象。过少的NET跟直立不耐症英语orthostatic intolerance相关,过多NET则和ADHD相关。[7][8]


参见

参考资料

  1. ^ 對Solute carrier family 6 member 2起作用的藥物;在維基數據上查看/編輯參考. 
  2. ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000103546 - Ensembl, May 2017
  3. ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000055368 - Ensembl, May 2017
  4. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  6. ^ Pacholczyk T, Blakely RD, Amara SG. Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter. Nature. Mar 1991, 350 (6316): 350–4. PMID 2008212. doi:10.1038/350350a0. 
  7. ^ Schroeter S, Apparsundaram S, Wiley RG, Miner LH, Sesack SR, Blakely RD. Immunolocalization of the cocaine- and antidepressant-sensitive l-norepinephrine transporter. The Journal of Comparative Neurology. May 2000, 420 (2): 211–32. PMID 10753308. doi:10.1002/(SICI)1096-9861(20000501)420:2<211::AID-CNE5>3.0.CO;2-3. 
  8. ^ Tellioglu T, Robertson D. Genetic or acquired deficits in the norepinephrine transporter: current understanding of clinical implications. Expert Reviews in Molecular Medicine. Nov 2001, 2001 (29): 1–10. PMID 14987367. doi:10.1017/S1462399401003878. 

外部链接