地来西坦

化合物

地来西坦(英语:Dimiracetam)是一种有机化合物,分子式C6H8N2O2,属于西坦类益智药[1],可用作神经性疼痛的药物[2]

地来西坦
IUPAC名
(RS)-3,6,7,7a-Tetrahydro-1H-pyrrolo[1,2-a]imidazole-2,5-dione
识别
CAS号 126100-97-8  checkY
PubChem 65955
ChemSpider 59358
SMILES
 
  • C1CC(=O)N2C1NC(=O)C2
InChI
 
  • 1/C6H8N2O2/c9-5-3-8-4(7-5)1-2-6(8)10/h4H,1-3H2,(H,7,9)
InChIKey XTXXOHPHLNROBN-UHFFFAOYAX
性质
化学式 C6H8N2O2
摩尔质量 140.14 g·mol−1
药理学
药品分级
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

参考文献

  1. ^ Pinza M, Farina C, Cerri A, Pfeiffer U, Riccaboni MT, Banfi S, et al. Synthesis and pharmacological activity of a series of dihydro-1H-pyrrolo[1,2-a]imidazole-2,5(3H,6H)-diones, a novel class of potent cognition enhancers. Journal of Medicinal Chemistry. December 1993, 36 (26): 4214–20. PMID 8277504. doi:10.1021/jm00078a011. 
  2. ^ Farina C, Gagliardi S, Ghelardini C, Martinelli M, Norcini M, Parini C, et al. Synthesis and biological evaluation of novel dimiracetam derivatives useful for the treatment of neuropathic pain. Bioorganic & Medicinal Chemistry. March 2008, 16 (6): 3224–32. PMID 18171618. doi:10.1016/j.bmc.2007.12.015. 

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