糖蛋白激素α亚基

糖蛋白激素α亚基（英语：Alpha subunit of glycoprotein hormones，或称为绒毛膜促性腺激素α亚基，Glycoprotein hormones alpha chain）是一个由人类基因CGA 编码的蛋白质。

Glycoprotein hormones, alpha polypeptide 绒毛膜促性腺激素，α多肽
PDB rendering based on 1dz7.
有效结构 PDB 直系同源检索：PDBe, RCSB PDB查询代码列表 1DZ7, 1E9J, 1FL7, 1HCN, 1HD4, 1HRP, 1QFW, 1XWD, 4AY9
标识
代号	CGA; CG-ALPHA; FSHA; GPHA1; GPHa; HCG; LHA; TSHA
扩展标识	遗传学：118850 鼠基因：88390 同源基因：587 GeneCards: CGA Gene
基因本体论描述 分子功能 · hormone activity · protein binding 细胞成分 · extracellular region 生物过程 · thyroid hormone generation · signal transduction · cell-cell signaling · positive regulation of cell proliferation · gonad development · peptide hormone processing · positive regulation of cell migration · thyroid gland development · luteinizing hormone secretion · cellular response to hormone stimulus · cellular protein metabolic process · positive regulation of transcription from RNA polymerase II promoter · negative regulation of organ growth · follicle-stimulating hormone secretion · developmental growth Sources: Amigo / QuickGO
RNA表达模式
更多表达数据
直系同源体
物种	人类	小鼠
Entrez	1081	12640
Ensembl	ENSG00000135346	ENSMUSG00000028298
UniProt	P01215	P01216
mRNA序列	NM_000735	NM_009889
蛋白序列	NP_000726	NP_034019
基因位置	Chr 6: 87.8 – 87.8 Mb	Chr 4: 34.89 – 34.91 Mb
PubMed查询	[1]	[2]

人体的四种糖蛋白激素--人绒毛膜促性腺激素（hCG）、黄体生成素（LH）、促卵泡激素（FSH）和促甲状腺激素（TSH）都是以同样的该α亚基和各自不同的β亚基组成的二聚体。

此α链的92个氨基酸残基的序列为：

NH₂ - Ala - Pro - Asp - Val - Gln - Asp - Cys - Pro - Glu - Cys - Thr - Leu - Gln - Glu - Asn - Pro - Phe - Phe - Ser - Gln - Pro - Gly - Ala - Pro - Ile - Leu - Gln - Cys - Met - Gly - Cys - Cys - Phe - Ser - Arg - Ala - Tyr - Pro - Thr - Pro - Leu - Arg - Ser - Lys - Lys - Thr - Met - Leu - Val - Gln - Lys - Asn - Val - Thr - Ser - Glu - Ser - Thr - Cys - Cys - Val - Ala - Lys - Ser - Tyr - Asn - Arg - Val - Thr - Val - Met - Gly - Gly - Phe - Lys - Val - Glu - Asn - His - Thr - Ala - Cys - His - Cys - Ser - Thr - Cys - Tyr - Tyr - His - Lys - Ser - COOH

延伸阅读

• Roger M, Lahlou N, Couzinet B; et al. [Free alpha-subunit glycoprotein hormones: physiological and pathological data]. J. Steroid Biochem. 1990, 33 (4B): 763–9. PMID 2481154. doi:10.1016/0022-4731(89)90489-5.  引文格式1维护：显式使用等标签 (link)
• Pierce JG. Eli Lilly lecture. The subunits of pituitary thyrotropin--their relationship to other glycoprotein hormones.. Endocrinology. 1972, 89 (6): 1331–44. PMID 5002675. doi:10.1210/endo-89-6-1331. 
• Kourides IA, Gurr JA, Wolf O. The regulation and organization of thyroid stimulating hormone genes.. Recent Prog. Horm. Res. 1984, 40: 79–120. PMID 6207569. 
• Miyoshi I, Kasai N, Hayashizaki Y. [Structure and regulation of human thyroid-stimulating hormone (TSH) gene]. Nippon Rinsho. 1994, 52 (4): 940–7. PMID 8196184. 
• Barrios-De-Tomasi J, Timossi C, Merchant H; et al. Assessment of the in vitro and in vivo biological activities of the human follicle-stimulating isohormones.. Mol. Cell. Endocrinol. 2002, 186 (2): 189–98. PMID 11900895. doi:10.1016/S0303-7207(01)00657-8.  引文格式1维护：显式使用等标签 (link)
• Moyle WR, Bahl OP, März L. Role of carbohydrate of human chorionic gonadotropin in the mechanism of hormone action.. J. Biol. Chem. 1976, 250 (23): 9163–9. PMID 172504. 
• Fiddes JC, Goodman HM. Isolation, cloning and sequence analysis of the cDNA for the alpha-subunit of human chorionic gonadotropin.. Nature. 1979, 281 (5730): 351–6. PMID 481597. doi:10.1038/281351a0. 
• Sairam MR, Li CH. Human pituitary thyrotropin. The primary structure of the alpha and beta subunits.. Can. J. Biochem. 1977, 55 (7): 755–60. PMID 890569. doi:10.1139/o77-108. 
• Morgan FJ, Birken S, Canfield RE. The amino acid sequence of human chorionic gonadotropin. The alpha subunit and beta subunit.. J. Biol. Chem. 1975, 250 (13): 5247–58. PMID 1150658. 
• Rathnam P, Saxena BB. Primary amino acid sequence of follicle-stimulating hormone from human pituitary glands. I. alpha subunit.. J. Biol. Chem. 1975, 250 (17): 6735–46. PMID 1158880. 
• Weisshaar G, Hiyama J, Renwick AG, Nimtz M. NMR investigations of the N-linked oligosaccharides at individual glycosylation sites of human lutropin.. Eur. J. Biochem. 1991, 195 (1): 257–68. PMID 1991473. doi:10.1111/j.1432-1033.1991.tb15702.x. 
• Sakakibara R, Yokoo Y, Yoshikoshi K; et al. Subcellular localization of intracellular forms of human chorionic gonadotropin in first trimester placenta.. J. Biochem. 1988, 102 (5): 993–1001. PMID 2449427.  引文格式1维护：显式使用等标签 (link)
• Matzuk MM, Keene JL, Boime I. Site specificity of the chorionic gonadotropin N-linked oligosaccharides in signal transduction.. J. Biol. Chem. 1989, 264 (5): 2409–14. PMID 2536708. 
• Lustbader JW, Birken S, Pileggi NF; et al. Crystallization and characterization of human chorionic gonadotropin in chemically deglycosylated and enzymatically desialylated states.. Biochemistry. 1990, 28 (24): 9239–43. PMID 2611225. doi:10.1021/bi00450a001.  引文格式1维护：显式使用等标签 (link)
• Harris DC, Machin KJ, Evin GM; et al. Preliminary X-ray diffraction analysis of human chorionic gonadotropin.. J. Biol. Chem. 1989, 264 (12): 6705–6. PMID 2708337.  引文格式1维护：显式使用等标签 (link)
• Hayashizaki Y, Miyai K, Kato K, Matsubara K. Molecular cloning of the human thyrotropin-beta subunit gene.. FEBS Lett. 1985, 188 (2): 394–400. PMID 3839756. doi:10.1016/0014-5793(85)80409-9. 
• Bellisario R, Carlsen RB, Bahl OP. Human chorionic gonadotropin. Linear amino acid sequence of the alpha subunit.. J. Biol. Chem. 1973, 248 (19): 6796–809. PMID 4745444. 
• Shome B, Parlow AF. Human follicle stimulating hormone (hFSH): first proposal for the amino acid sequence of the alpha-subunit (hFSHa) and first demonstration of its identity with the alpha-subunit of human luteinizing hormone (hLHa).. J. Clin. Endocrinol. Metab. 1974, 39 (1): 199–202. PMID 4835135. doi:10.1210/jcem-39-1-199. 

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