阿法骨化醇
阿法骨化醇(英语:Alfacalcidol,也称为1-羟基胆钙化醇,1-hydroxycholecalciferol)是一种含氮有机化合物,化学式C27H44O2,属于维生素D类似物[3]。
阿法骨化醇 | |
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IUPAC名 (1R,3S,5Z)-4-Methylidene-5-[(2E)-2-{(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]octahydro-4H-inden-4-ylidene}ethylidene]cyclohexane-1,3-diol | |
别名 | Alphacalcidol; 1-Hydroxycholecalciferol |
识别 | |
CAS号 | 41294-56-8 |
PubChem | 5282181 |
ChemSpider | 4445376 |
SMILES |
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InChI |
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InChIKey | OFHCOWSQAMBJIW-AVJTYSNKBM |
ChEBI | 31186 |
DrugBank | DB01436 |
KEGG | D01518 |
性质 | |
化学式 | C27H44O2 |
摩尔质量 | 400.64 g/mol g·mol⁻¹ |
熔点 | 136 °C(409 K) |
溶解性(水) | 0.016 g/100 mL |
药理学 | |
ATC代码 | A11CC03(A11) |
药品分级 | |
药品许可证 | |
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。 |
参考文献
- ^ One-Alpha Capsules - Summary of Product Characteristics (SmPC). (emc). 9 November 2017 [17 February 2021]. (原始内容存档于2024-02-25).
- ^ List of nationally authorised medicinal products (PDF). ema.europa.eu. 11 February 2021 [14 April 2023].
- ^ Cavalli L, Cavalli T, Marcucci G, Falchetti A, Masi L, Brandi ML. Biological effects of various regimes of 25-hydroxyvitamin D3 (calcidiol) administration on bone mineral metabolism in postmenopausal women. Clinical Cases in Mineral and Bone Metabolism. May 2009, 6 (2): 169–73. PMC 2781231 . PMID 22461169.