Ki-67 (蛋白质)

Ki-67
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1R21、2AFF
识别号
别名	MKI67；, marker of proliferation Ki-67, KIA, MIB-, MIB-1, PPP1R105
外部ID	OMIM：176741 MGI：106035 HomoloGene：1814 GeneCards：MKI67
基因位置（人类）
染色体	10号染色体
终止	128,126,423 bp
基因位置（小鼠）
染色体	小鼠7号染色体
终止	135,318,090 bp
基因本体
分子功能	• 核苷酸结合; • protein C-terminus binding; • 血浆蛋白结合; • ATP结合; • DNA结合; • RNA binding;
细胞组分	• 细胞质; • 膜; • 染色体; • 核仁; • 着丝粒; • 细胞核; • condensed chromosome; • nuclear body;
生物学过程	• cellular response to heat; • response to organic cyclic compound; • DNA代谢过程; • animal organ regeneration; • hyaluronan metabolic process; • 细胞周期; • regulation of chromosome segregation; • 细胞增殖; • regulation of mitotic nuclear division; • regulation of chromatin organization; • 减数分裂;
	Sources:Amigo / QuickGO
直系同源
	4288
	17345
	ENSG00000148773
	ENSMUSG00000031004
	P46013
	E9PVX6
	NM_001145966; NM_002417
	NM_001081117
	NP_001139438; NP_002408
	NP_001074586
	维基数据
查看/编辑人类	查看/编辑小鼠

Ki-67（MKI67）是一种由人MKI67基因编码的蛋白质^[5]^[6]^[7]。该蛋白与细胞的增殖密切相关，在有丝分裂期以及分裂间期的细胞（G₁、S、G₂、M期）中都能检出Ki-67蛋白，有丝分裂停止的细胞（G₀期）中则无Ki-67蛋白质存在。另外，研究发现使Ki-67失活可以抑制rRNA的合成，提示Ki-67蛋白与rRNA（核糖体RNA）的转录密切相关^[7]^[8]。

参考

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000148773 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000031004 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Entrez Gene: Antigen identified by monoclonal antibody Ki-67.
^ Schonk DM, Kuijpers HJ, van Drunen E, van Dalen CH, Geurts van Kessel AH, Verheijen R, Ramaekers FC. Assignment of the gene(s) involved in the expression of the proliferation-related Ki-67 antigen to human chromosome 10. Hum. Genet. October 1989, 83 (3): 297–9. PMID 2571566. doi:10.1007/BF00285178.
^ ^7.0 ^7.1 Bullwinkel J, Baron-Lühr B, Lüdemann A, Wohlenberg C, Gerdes J, Scholzen T. Ki-67 protein is associated with ribosomal RNA transcription in quiescent and proliferating cells. J. Cell. Physiol. March 2006, 206 (3): 624–35. PMID 16206250. doi:10.1002/jcp.20494.
^ Rahmanzadeh R, Hüttmann G, Gerdes J, Scholzen T. Chromophore-assisted light inactivation of pKi-67 leads to inhibition of ribosomal RNA synthesis. Cell Prolif. June 2007, 40 (3): 422–30. PMID 17531085. doi:10.1111/j.1365-2184.2007.00433.x.

外部链接

医学主题词表（MeSH）：Ki-67+Antigen

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000148773 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000031004 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] Entrez Gene: Antigen identified by monoclonal antibody Ki-67.

[pmid2571566-6] Schonk DM, Kuijpers HJ, van Drunen E, van Dalen CH, Geurts van Kessel AH, Verheijen R, Ramaekers FC. Assignment of the gene(s) involved in the expression of the proliferation-related Ki-67 antigen to human chromosome 10. Hum. Genet. October 1989, 83 (3): 297–9. PMID 2571566. doi:10.1007/BF00285178.

[pmid16206250-7] 7.0 ^7.1 Bullwinkel J, Baron-Lühr B, Lüdemann A, Wohlenberg C, Gerdes J, Scholzen T. Ki-67 protein is associated with ribosomal RNA transcription in quiescent and proliferating cells. J. Cell. Physiol. March 2006, 206 (3): 624–35. PMID 16206250. doi:10.1002/jcp.20494.

[pmid17531085-8] Rahmanzadeh R, Hüttmann G, Gerdes J, Scholzen T. Chromophore-assisted light inactivation of pKi-67 leads to inhibition of ribosomal RNA synthesis. Cell Prolif. June 2007, 40 (3): 422–30. PMID 17531085. doi:10.1111/j.1365-2184.2007.00433.x.

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