P73

p73，又称为TP73，是p53蛋白家族的成员之一，以其分子量为73kD而得名，存在多种转录变体。p73的结构和功能均与p53类似，为肿瘤抑制蛋白，能调控细胞增殖并促进细胞凋亡。过表达p73的细胞增殖会停止。

P73
已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 4GUQ、​1COK、​1DXS、​2KBY、​2MPS、​2WQI、​2WQJ、​2WTT、​2XWC、​3VD0、​3VD1、​3VD2、​4A63、​4G82、​4G83、​4GUO
识别号
别名	TP73；, P73, tumor protein p73, CILD47
外部ID	OMIM：601990 MGI：1336991 HomoloGene：3960 GeneCards：TP73
基因位置（人类） 染色体 1号染色体 基因座 1p36.32 起始 3,652,516 bp 终止 3,736,201 bp
基因位置（小鼠） 染色体 小鼠4号染色体 基因座 4 E2|4 83.79 cM 起始 154,140,706 bp 终止 154,224,665 bp
RNA表达模式
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基因本体 分子功能 • DNA结合 • sequence-specific DNA binding • DNA-binding transcription activator activity, RNA polymerase II-specific • 转录因子结合 • chromatin binding • 金属离子结合 • RNA polymerase II cis-regulatory region sequence-specific DNA binding • damaged DNA binding • 血浆蛋白结合 • 相同蛋白质结合 • protein kinase binding • p53 binding • DNA结合转录因子活性 • MDM2/MDM4 family protein binding • DNA-binding transcription factor activity, RNA polymerase II-specific 细胞组分 • 细胞质 • 高尔基体 • 细胞内膜结合细胞器 • 转录调节复合物 • 细胞连接 • 染色质 • 细胞核 • 线粒体 • 核质 • 细胞质基质 生物学过程 • negative regulation of neuron apoptotic process • positive regulation of oligodendrocyte differentiation • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • regulation of transcription, DNA-templated • negative regulation of neuron differentiation • 肾的发生 • cellular response to UV • negative regulation of transcription by RNA polymerase II • protein tetramerization • transcription, DNA-templated • cellular response to DNA damage stimulus • mitotic G1 DNA damage checkpoint signaling • response to organonitrogen compound • intrinsic apoptotic signaling pathway in response to DNA damage • regulation of mitotic cell cycle • positive regulation of apoptotic process • 基因调节 • DNA错配修复 • 细胞周期 • negative regulation of cardiac muscle cell proliferation • viral process • negative regulation of JUN kinase activity • response to gamma radiation • response to X-ray • positive regulation of transcription by RNA polymerase II • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • negative regulation of cell population proliferation • 细胞凋亡 • regulation of signal transduction by p53 class mediator • transcription by RNA polymerase II • regulation of apoptotic process • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • positive regulation of transcription, DNA-templated • regulation of hematopoietic stem cell differentiation Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	7161	22062
Ensembl	ENSG00000078900	ENSMUSG00000029026
UniProt	O15350	Q9JJP2
mRNA​序列	NM_001126240 ​NM_001126241 ​NM_001126242 ​NM_001204184 ​NM_001204185 ​NM_001204186 ​NM_001204187 ​NM_001204188 ​NM_001204189 ​NM_001204190 ​NM_001204191 ​NM_001204192 ​NM_005427	NM_001126330 ​NM_001126331 ​NM_011642
蛋白序列	NP_001119712 ​NP_001119713 ​NP_001119714 ​NP_001191113 ​NP_001191114 ​NP_001191115 ​NP_001191116 ​NP_001191117 ​NP_001191118 ​NP_001191119 ​NP_001191120 ​NP_001191121 ​NP_005418	NP_001119802 ​NP_001119803 ​NP_035772
基因位置​（UCSC）	Chr 1: 3.65 – 3.74 Mb	Chr 4: 154.14 – 154.22 Mb
PubMed​查找
维基数据
查看/编辑人类 查看/编辑小鼠

参见

• p53
• p63

参考文献

• Kaghad, M.; Bonnet, H.; Yang, A.; Creancier, L.; Biscan, J. C.; Valent, A.; Minty, A.; Chalon, P.; Lelias, J. M. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell. 1997-08-22, 90 (4): 809–819 [2021-11-10]. ISSN 0092-8674. PMID 9288759. doi:10.1016/s0092-8674(00)80540-1. （原始内容存档于2022-02-23）. 
• Levrero, M.; De Laurenzi, V.; Costanzo, A.; Gong, J.; Wang, J. Y.; Melino, G. The p53/p63/p73 family of transcription factors: overlapping and distinct functions. Journal of Cell Science. 2000-05,. 113 ( Pt 10): 1661–1670 [2021-11-10]. ISSN 0021-9533. PMID 10769197. （原始内容存档于2022-03-01）. 
• Pozniak, Christine D.; Radinovic, Stevo; Yang, Annie; McKeon, Frank; Kaplan, David R.; Miller, Freda D. An Anti-Apoptotic Role for the p53 Family Member, p73, During Developmental Neuron Death. Science. 2000-07-14, 289 (5477): 304–306 [2021-11-10]. ISSN 0036-8075. PMID 10894779. doi:10.1126/science.289.5477.304. （原始内容存档于2021-11-10） （英语）. 
• Yang, Annie; Walker, Nancy; Bronson, Roderick; Kaghad, Mourad; Oosterwegel, Mariette; Bonnin, Jacques; Vagner, Christine; Bonnet, Helene; Dikkes, Pieter. p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours. Nature. 2000-03, 404 (6773): 99–103 [2021-11-10]. ISSN 0028-0836. PMID 10716451. doi:10.1038/35003607. （原始内容存档于2022-01-28） （英语）. 
• Kaelin, W. G. The emerging p53 gene family. Journal of the National Cancer Institute. 1999-04-07, 91 (7): 594–598 [2021-11-10]. ISSN 0027-8874. PMID 10203277. doi:10.1093/jnci/91.7.594. （原始内容存档于2021-11-10）. 
• Davis, P. K.; Dowdy, S. F. p73. The International Journal of Biochemistry & Cell Biology. 2001-10, 33 (10): 935–939 [2021-11-10]. ISSN 1357-2725. PMID 11470228. doi:10.1016/s1357-2725(01)00073-5. （原始内容存档于2021-11-10）. 
• Salomoni, Paolo; Pandolfi, Pier Paolo. The role of PML in tumor suppression. Cell. 2002-01-25, 108 (2): 165–170 [2021-11-10]. ISSN 0092-8674. PMID 11832207. doi:10.1016/s0092-8674(02)00626-8. （原始内容存档于2022-03-02）. 
• Melino, Gerry. p73, the "assistant" guardian of the genome?. Annals of the New York Academy of Sciences. 2003-12, 1010: 9–15 [2021-11-10]. ISSN 0077-8923. PMID 15033688. doi:10.1196/annals.1299.002. （原始内容存档于2021-11-10）. 
• Jacobs, W. Bradley; Walsh, Gregory S.; Miller, Freda D. Neuronal survival and p73/p63/p53: a family affair. The Neuroscientist: A Review Journal Bringing Neurobiology, Neurology and Psychiatry. 2004-10, 10 (5): 443–455 [2021-11-10]. ISSN 1073-8584. PMID 15359011. doi:10.1177/1073858404263456. （原始内容存档于2022-02-25）. 
• Rossi, Mario; Sayan, A. Emre; Terrinoni, Alessandro; Melino, Gerry; Knight, Richard A. Mechanism of induction of apoptosis by p73 and its relevance to neuroblastoma biology. Annals of the New York Academy of Sciences. 2004-12, 1028: 143–149 [2021-11-10]. ISSN 0077-8923. PMID 15650240. doi:10.1196/annals.1322.015. （原始内容存档于2021-11-10）. 
• Dobbelstein M, Strano S, Roth J, Blandino G. p73-induced apoptosis: a question of compartments and cooperation.. Biochem. Biophys. Res. Commun. 2005, 331 (3): 688–93. PMID 15865923. doi:10.1016/j.bbrc.2005.03.155. 
• Ramadan, Saafa; Terrinoni, Alessandro; Catani, Maria Valeria; Sayan, A. Emre; Knight, Richard A.; Mueller, Martina; Krammer, Peter H.; Melino, Gerry; Candi, Eleonora. p73 induces apoptosis by different mechanisms. Biochemical and Biophysical Research Communications. 2005-06-10, 331 (3): 713–717 [2021-11-10]. ISSN 0006-291X. PMID 15865927. doi:10.1016/j.bbrc.2005.03.156. （原始内容存档于2021-11-10）. 
• Harms, Kelly Lynn; Chen, Xinbin. p19 ras Brings a New Twist to the Regulation of p73 by Mdm2. Science's STKE. 2006-05-30, 2006 (337) [2021-11-10]. ISSN 1525-8882. PMID 16738062. doi:10.1126/stke.3372006pe24. （原始内容存档于2022-03-11） （英语）. 
• Marabese, Mirko; Vikhanskaya, Faina; Broggini, Massimo. p73: a chiaroscuro gene in cancer. European Journal of Cancer (Oxford, England: 1990). 2007-06, 43 (9): 1361–1372 [2021-11-10]. ISSN 0959-8049. PMID 17428654. doi:10.1016/j.ejca.2007.01.042. （原始内容存档于2021-11-10）. 
• Levy, D; Adamovich, Y; Reuven, N; Shaul, Y. The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73. Cell Death & Differentiation. 2007-04, 14 (4): 743–751 [2021-11-10]. ISSN 1350-9047. PMID 17110958. doi:10.1038/sj.cdd.4402063. （原始内容存档于2022-03-08） （英语）.