模板:PBB/920

CD4 molecule
CD4分子
CD4 molecule; CD4分子
	Crystallographic structure of the V-set and C2 domains of human CD4.
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1CDH, 1CDI, 1CDJ, 1CDU, 1CDY, 1G9M, 1G9N, 1GC1, 1JL4, 1Q68, 1RZJ, 1RZK, 1WBR, 1WIO, 1WIP, 1WIQ, 2B4C, 2JKR, 2JKT, 2KLU, 2NXY, 2NXZ, 2NY0, 2NY1, 2NY2, 2NY3, 2NY4, 2NY5, 2NY6, 2QAD, 3B71, 3CD4, 3JWD, 3JWO, 3LQA, 3O2D, 3S4S, 3S5L, 3T0E, 4JM2
标识
代号	CD4; CD4mut
扩展标识	遗传学：186940 鼠基因：88335 同源基因：513 ChEMBL: 2754 GeneCards: CD4 Gene
基因本体论描述
分子功能	· glycoprotein binding; · receptor activity; · transmembrane signaling receptor activity; · extracellular matrix structural constituent; · protein binding; · zinc ion binding; · coreceptor activity; · enzyme binding; · protein kinase binding; · MHC class II protein binding; · protein homodimerization activity;
细胞成分	· early endosome; · endoplasmic reticulum lumen; · endoplasmic reticulum membrane; · plasma membrane; · external side of plasma membrane; · integral to membrane; · T cell receptor complex; · membrane raft;
生物过程	· cytokine production; · induction by virus of host cell-cell fusion; · immune response; · cell adhesion; · signal transduction; · cell surface receptor signaling pathway; · enzyme linked receptor protein signaling pathway; · transmembrane receptor protein tyrosine kinase signaling pathway; · viral reproduction; · viral reproductive process; · T cell differentiation; · entry into host cell; · T cell costimulation; · maintenance of protein location in cell; · T cell selection; · positive regulation of interleukin-2 biosynthetic process; · innate immune response; · protein palmitoleylation; · positive regulation of protein kinase activity; · regulation of defense response to virus by virus; · positive regulation of peptidyl-tyrosine phosphorylation; · defense response to Gram-negative bacterium; · positive regulation of calcium-mediated signaling; · T cell receptor signaling pathway; · regulation of T cell activation;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	920
Ensembl	ENSG00000010610
UniProt	P01730
mRNA序列	NM_000616
蛋白序列	NP_000607
基因位置	Chr 12:; 6.9 – 6.93 Mb
PubMed查询	[1]
	查; 论; 编;

参考资料

^ PDB 1cdh; Ryu SE, Truneh A, Sweet RW, Hendrickson WA. Structures of an HIV and MHC binding fragment from human CD4 as refined in two crystal lattices. Structure. January 1994, 2 (1): 59–74. PMID 8075984.

[pmid8075984-1] PDB 1cdh; Ryu SE, Truneh A, Sweet RW, Hendrickson WA. Structures of an HIV and MHC binding fragment from human CD4 as refined in two crystal lattices. Structure. January 1994, 2 (1): 59–74. PMID 8075984.

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