1-異硫氰基-6-甲亞磺酰基己烷

化合物

1-異硫氰基-6-甲亞磺酰基己烷異硫氰酸-6-甲亞磺酰基己酯是一種有機化合物,化學式為C8H15NOS2。它可由6-溴己腈甲硫醇鈉二硫化碳間氯過氧苯甲酸為原料反應得到。[1]它存在於山葵中,是一種糖原合酶激酶3β英語GSK-3抑制劑。[2]有文獻對其抗癌作用做了小鼠實驗。[3]

1-異硫氰基-6-甲亞磺酰基己烷
IUPAC名
1-Isothiocyanato-6-(methanesulfinyl)hexane
別名 6-MITC; 6-MSITC
異硫氰酸(6-甲亞磺酰基)己酯
(6-甲基亞磺酰基)己基硫氰酸酯
識別
CAS號 4430-35-7  checkY
PubChem 9815648
ChemSpider 7991398
SMILES
 
  • CS(=O)CCCCCN=C=S
ChEBI 138799
性質
化學式 C8H15NOS2
摩爾質量 205.34 g·mol−1
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。

參考文獻

  1. ^ Ashida, Hitoshi; Hashimoto, Takashi. Cell cycle inhibitors containing Brassicaceae isothiocyanates, and topical preparations, cosmetics, and health foods containing them. 2006 JP 2006089394 A.
  2. ^ Jun Yoshida, Satomi Nomura, Naoyuki Nishizawa, Yoshiaki Ito, Ken-ichi Kimura. Glycogen Synthase Kinase-3β Inhibition of 6-(Methylsulfinyl)hexyl Isothiocyanate Derived from Wasabi ( Wasabia japonica Matsum). Bioscience, Biotechnology, and Biochemistry. 2011-01-23, 75 (1): 136–139 [2022-02-26]. ISSN 0916-8451. doi:10.1271/bbb.100507 (英語). 
  3. ^ Yoko Fuke, Yoshiko Haga, Haruhiro Ono, Takahiro Nomura, Kazuo Ryoyama. Anti-carcinogenic activity of 6-methylsulfinylhexyl isothiocyanate-, an active anti-proliferative principal of wasabi (Eutrema wasabi Maxim.). Cytotechnology. 1997-11-01, 25 (1): 197 [2022-02-26]. ISSN 1573-0778. PMC 3466737 . PMID 22358892. doi:10.1023/A:1007918508115 (英語).