2-丁基-3-(4-甲苯基)奎寧環

化合物

2-丁基-3-(4-甲苯基)奎寧環(英語:2-Butyl-3-(p-tolyl)quinuclidine,Butyltolylquinuclidine,縮寫BTQ)是一種具有興奮劑功能的多巴胺再攝取抑制劑[1],是含奎寧環的藥物之一,是治療可卡因濫用的潛在藥物之一[2],更加溫和持久,在動物研究中產生與可卡因相似的效果。

2-丁基-3-(4-甲苯基)奎寧環
Skeletal formula of butyltolylquinuclidine
Ball-and-stick model of the butyltolylquinuclidine molecule
臨床資料
ATC碼
  • 未分配
法律規範狀態
法律規範
  • Legal
識別資訊
  • (2R,3S,4S)-2-butyl-3-p-tolylquinuclidine
CAS號328047-48-9
PubChem CID
ChemSpider
UNII
化學資訊
化學式C18H27N
摩爾質量257.42 g·mol−1
3D模型(JSmol英語JSmol
  • C3CC1CCN3C(CCCC)C1c(cc2)ccc2C
  • InChI=1S/C18H27N/c1-3-4-5-17-18(15-8-6-14(2)7-9-15)16-10-12-19(17)13-11-16/h6-9,16-18H,3-5,10-13H2,1-2H3
  • Key:QYIZEJQSBLRXJK-UHFFFAOYSA-N

參見

參考文獻

  1. ^ Sakamuri S, Enyedy IJ, Zaman WA, Tella SR, Kozikowski AP, Flippen-Anderson JL, et al. 2,3-Disubstituted quinuclidines as a novel class of dopamine transporter inhibitors. Bioorganic & Medicinal Chemistry. March 2003, 11 (6): 1123–36. PMID 12614900. doi:10.1016/S0968-0896(02)00450-9. 
  2. ^ Enyedy IJ, Sakamuri S, Zaman WA, Johnson KM, Wang S. Pharmacophore-based discovery of substituted pyridines as novel dopamine transporter inhibitors. Bioorganic & Medicinal Chemistry Letters. February 2003, 13 (3): 513–7. PMID 12565962. doi:10.1016/S0960-894X(02)00943-5.