CpG寡脫氧核苷酸
CpG寡脫氧核苷酸（英語：CpG oligodeoxynucleotides，CpG ODN）是短的單鏈DNA分子，其序列包含一個胞嘧啶脫氧核苷酸 ("C")，緊接着一個 鳥嘌呤脫氧核苷酸 ("G")，"p"是指兩者之間的磷酸二酯鍵鏈接。當CpG寡脫氧核苷酸處於未甲基化的狀態時，可以作為免疫增強劑[1]。未甲基化的CpG ODN是一種病原相關分子模式，因為其在脊椎動物的基因組中很稀有，而在微生物的基因組中很豐富。[2]。CpG ODN是公認的模式識別受體（PRR）Toll樣受9（TLR9）的配體，TLR9隻在人類和其他較高的靈長類動物的B細胞和漿細胞樣樹突狀細胞（pDC）中表達。[3]
參考文獻
- ^ Weiner, GJ; Liu, HM; Wooldridge, JE; Dahle, CE; Krieg, AM. Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization. Proceedings of the National Academy of Sciences of the United States of America. 1997, 94 (20): 10833–7. PMC 23500
. PMID 9380720. doi:10.1073/pnas.94.20.10833.
- ^ Bauer, S; Wagner, H. Bacterial CpG-DNA licenses TLR9. Current topics in microbiology and immunology. Current Topics in Microbiology and Immunology. 2002, 270: 145–54. ISBN 978-3-642-63975-3. PMID 12467249. doi:10.1007/978-3-642-59430-4_9.
- ^ Rothenfusser, S; Tuma, E; Endres, S; Hartmann, G. Plasmacytoid dendritic cells: the key to CpG. Human immunology. 2002, 63 (12): 1111–9. PMID 12480254. doi:10.1016/S0198-8859(02)00749-8.
