羅索那班

羅索那班
臨床資料
ATC碼	未分配;
識別資訊
	IUPAC命名法 (±)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(1-piperidinyl)-4,5-dihydro-1H-pyrazole-3-carboxamide; ;
CAS號	861151-12-4
PubChem CID	11316914;
ChemSpider	9491881;
UNII	7X5RY2T485;
CompTox Dashboard（英語：CompTox Chemicals Dashboard） (EPA)	DTXSID201006613 ;
化學資訊
化學式	C21H21Cl3N4O
摩爾質量	451.78 g·mol−1
3D模型（JSmol（英語：JSmol））	交互式圖像;
	SMILES O=C(NN1CCCCC1)\C4=N\N(c2ccc(Cl)cc2Cl)C(c3ccc(Cl)cc3)C4;
	InChI InChI=1S/C21H21Cl3N4O/c22-15-6-4-14(5-7-15)20-13-18(21(29)26-27-10-2-1-3-11-27)25-28(20)19-9-8-16(23)12-17(19)24/h4-9,12,20H,1-3,10-11,13H2,(H,26,29); Key:WMMMJGKFKKBRQR-UHFFFAOYSA-N;

羅索那班（INN：Rosonabant，開發代號：E-6776）或譯作羅索納班，是一種用作CB₁受體拮抗劑/反向激動劑的藥物，埃斯特夫正在研究將其作為治療肥胖症的食慾抑制劑。^[1]^[2]在相關的CB₁拮抗劑利莫那班於2008年11月停用後不久，臨床用藥的開發明顯停止，原因是有報道稱其及其它類似藥劑會引起嚴重的精神不良反應，例如焦慮、抑鬱和自殺意念。^[3]^[4]^[5]

參見

^ Janero DR, Makriyannis A. Cannabinoid receptor antagonists: pharmacological opportunities, clinical experience, and translational prognosis. Expert Opinion on Emerging Drugs. March 2009, 14 (1): 43–65. PMID 19249987. S2CID 74250986. doi:10.1517/14728210902736568.
^ Tim C. Kirkham; S. J. Cooper. Appetite and Body Weight: Integrative Systems and the Development of Anti-Obesity Drugs. Academic Press. 2007: 325 [12 May 2012]. ISBN 978-0-12-370633-1.
^ Heal DJ, Gosden J, Smith SL. Regulatory challenges for new drugs to treat obesity and comorbid metabolic disorders. British Journal of Clinical Pharmacology. December 2009, 68 (6): 861–74. PMC 2810797  . PMID 20002080. doi:10.1111/j.1365-2125.2009.03549.x.
^ Lee HK, Choi EB, Pak CS. The current status and future perspectives of studies of cannabinoid receptor 1 antagonists as anti-obesity agents. Current Topics in Medicinal Chemistry. 2009, 9 (6): 482–503. PMID 19689362. doi:10.2174/156802609788897844. （原始內容存檔於2013-05-22）.
^ Moreira, Fabrício A.; Crippa, José Alexandre S. The psychiatric side-effects of rimonabant. Revista Brasileira de Psiquiatria. June 2009, 31 (2): 145–153. ISSN 1516-4446. PMID 19578688. doi:10.1590/S1516-44462009000200012  .

臨床資料

ATC碼	未分配
識別資訊
IUPAC命名法 (±)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(1-piperidinyl)-4,5-dihydro-1H-pyrazole-3-carboxamide
CAS號	861151-12-4
PubChem CID	11316914
ChemSpider	9491881
UNII	7X5RY2T485
CompTox Dashboard（英語：CompTox Chemicals Dashboard） (EPA)	DTXSID201006613
化學資訊
化學式	C₂₁H₂₁Cl₃N₄O
摩爾質量	451.78 g·mol⁻¹
3D模型（JSmol（英語：JSmol））	交互式圖像
SMILES O=C(NN1CCCCC1)\C4=N\N(c2ccc(Cl)cc2Cl)C(c3ccc(Cl)cc3)C4
InChI InChI=1S/C21H21Cl3N4O/c22-15-6-4-14(5-7-15)20-13-18(21(29)26-27-10-2-1-3-11-27)25-28(20)19-9-8-16(23)12-17(19)24/h4-9,12,20H,1-3,10-11,13H2,(H,26,29) Key:WMMMJGKFKKBRQR-UHFFFAOYSA-N