胱天蛋白酶5

CASP5
識別號
別名	CASP5；, ICE(rel)III, ICEREL-III, ICH-3, caspase 5
外部ID	OMIM：602665 MGI：107700 HomoloGene：129949 GeneCards：CASP5
基因位置（人類）
染色體	11號染色體
終止	105,023,168 bp
基因位置（小鼠）
染色體	小鼠9號染色體
終止	5,336,783 bp
基因本體
分子功能	• 肽酶活性; • 半胱氨酸型肽酶活性; • 水解酶活性; • scaffold protein binding; • cysteine-type endopeptidase activity involved in execution phase of apoptosis; • cysteine-type endopeptidase activity involved in apoptotic process; • cysteine-type endopeptidase activity; • cysteine-type endopeptidase activity involved in apoptotic signaling pathway; • 血漿蛋白結合;
細胞組分	• NLRP3 inflammasome complex; • AIM2 inflammasome complex; • IPAF inflammasome complex; • NLRP1 inflammasome complex; • soma; • neuron projection; • 細胞質;
生物學過程	• regulation of apoptotic process; • ectopic germ cell programmed cell death; • cellular response to mechanical stimulus; • substantia nigra development; • 細胞焦亡; • 蛋白酶解; • regulation of inflammatory response; • 細胞凋亡; • execution phase of apoptosis; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • apoptotic signaling pathway;
	Sources:Amigo / QuickGO
直系同源
	838
	12363
	ENSG00000137757
	ENSMUSG00000033538
	P51878
	P70343
	NM_001136109; NM_001136110; NM_001136112; NM_004347
	NM_007609
	NP_001129581; NP_001129582; NP_001129584; NP_004338
NP_031635; NP_001366247; NP_001366248; NP_001366249; NP_001366250;
	NP_001366251; NP_001366252
	維基數據
檢視/編輯人類	檢視/編輯小鼠

胱天蛋白酶5（英語：Caspase 5）是一種在人類中由CASP5基因編碼的酶，屬於胱天蛋白酶家族。該酶是一種在天冬氨酸殘基處以蛋白水解方式裂解其他蛋白質的酶。該酶與胱天蛋白酶1、4以及鼠同源物胱天蛋白酶11一樣，都是一種炎性胱天蛋白酶，在免疫系統中發揮作用。^[5]

參見

蛋白酶解圖譜（英語：The Proteolysis Map）
胱天蛋白酶

參考文獻

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000137757 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000033538 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Martinon F, Tschopp J. Inflammatory caspases and inflammasomes: master switches of inflammation. Cell Death Differ. 2007, 14 (1): 10–22. PMID 16977329. doi:10.1038/sj.cdd.4402038  .

外部連結

肽酶及其抑制劑的MEROPS在線數據庫：C14.008^{[失效連結]}

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000137757 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000033538 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Martinon F, Tschopp J. Inflammatory caspases and inflammasomes: master switches of inflammation. Cell Death Differ. 2007, 14 (1): 10–22. PMID 16977329. doi:10.1038/sj.cdd.4402038  .

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